Cargando…

The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes

Neonatal diabetes mellitus (NDM) is a monogenic disorder caused by mutations in genes involved in regulation of insulin secretion from pancreatic β-cells. Mutations in the KCNJ11 and ABCC8 genes, encoding the adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channel Kir6.2 and SUR1 subunits,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lang, Veronica, Light, Peter E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513215/ https://www.ncbi.nlm.nih.gov/pubmed/23226049 http://dx.doi.org/10.2147/PGPM.S6969

Ejemplares similares

Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity
por: Fatehi, Mohammad, et al.
Publicado: (2015)

K(ATP) Channel Mutations and Neonatal Diabetes
por: Shimomura, Kenju, et al.
Publicado: (2017)

Endothelial biology and ATP-sensitive potassium channels
por: Aziz, Qadeer, et al.
Publicado: (2018)

Identification of an ATP-sensitive potassium channel in mitochondria
por: Paggio, Angela, et al.
Publicado: (2019)

Molecular Mechanism of Sulphonylurea Block of K(ATP) Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes
por: Proks, Peter, et al.
Publicado: (2013)

Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats
por: Chen, Zhih-Cherng, et al.
Publicado: (2012)

Transient neonatal diabetes due to a missense mutation (E227K) in the gene encoding the ATP-sensitive potassium channel (KCNJ11)
por: Martins, Luísa, et al.
Publicado: (2015)

Modulatory Effect of Medicinal Plants and Their Active Constituents on ATP-Sensitive Potassium Channels (K(ATP)) in Diabetes
por: Al Kury, Lina T.
Publicado: (2023)

Neonatal Diabetes and the K(ATP) Channel: From Mutation to Therapy
por: Ashcroft, Frances M., et al.
Publicado: (2017)

ATP-sensitive potassium channel (K(ATP )channel) expression in the normal canine pancreas and in canine insulinomas
por: Donley, Vicky R, et al.
Publicado: (2005)

Expression of ATP-sensitive potassium channels in human pregnant myometrium
por: Xu, Chen, et al.
Publicado: (2011)

Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels
por: Martin, Gregory M., et al.
Publicado: (2013)

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating
por: Martin, Gregory M, et al.
Publicado: (2017)

The ATP sensitive potassium channel (K(ATP)) is a novel target for migraine drug development
por: Clement, Amalie, et al.
Publicado: (2023)

Evidence for the Participation of ATP-sensitive Potassium Channels in the Antinociceptive Effect of Curcumin
por: De Paz-Campos, Marco Antonio, et al.
Publicado: (2012)

Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
por: Turzo, Maurizio, et al.
Publicado: (2018)

ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential
por: Clement, Amalie, et al.
Publicado: (2022)

Structural Insights into ATP-Sensitive Potassium Channel Mechanics: A Role of Intrinsically Disordered Regions
por: Walczewska-Szewc, Katarzyna, et al.
Publicado: (2023)

Phosphoinositides Decrease Atp Sensitivity of the Cardiac Atp-Sensitive K(+) Channel: A Molecular Probe for the Mechanism of Atp-Sensitive Inhibition
por: Fan, Zheng, et al.
Publicado: (1999)

Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads
por: Zhu, Zhiyong, et al.
Publicado: (2014)

Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel
por: Laskowski, Michał, et al.
Publicado: (2019)

Associations of ATP-Sensitive Potassium Channel’s Gene Polymorphisms With Type 2 Diabetes and Related Cardiovascular Phenotypes
por: Liu, Cheng, et al.
Publicado: (2022)

Mutations within the P-Loop of Kir6.2 Modulate the Intraburst Kinetics of the Atp-Sensitive Potassium Channel
por: Proks, Peter, et al.
Publicado: (2001)

ATP-Sensitive Potassium Channel-Deficient Mice Show Hyperphagia but Are Resistant to Obesity
por: Park, Yeul Bum, et al.
Publicado: (2011)

Functional protection against cardiac diseases depends on ATP‐sensitive potassium channels
por: Ye, Peng, et al.
Publicado: (2018)

Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis
por: Li, Yiwen, et al.
Publicado: (2020)

The Potential Role of Activating the ATP-Sensitive Potassium Channel in the Treatment of Hyperphagic Obesity
por: Cowen, Neil, et al.
Publicado: (2020)

Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels
por: Specterman, Mark J., et al.
Publicado: (2023)

Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K(+) Channel
por: Hamming, Kevin S.C., et al.
Publicado: (2009)

Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP
por: Trapp, Stefan, et al.
Publicado: (1998)

Photo-Switchable Sulfonylureas Binding to ATP-Sensitive Potassium Channel Reveal the Mechanism of Light-Controlled Insulin Release
por: Walczewska-Szewc, Katarzyna, et al.
Publicado: (2021)

Role of Hsp90 in Biogenesis of the β-Cell ATP-sensitive Potassium Channel Complex
por: Yan, Fei-Fei, et al.
Publicado: (2010)

Mitochondria from rat uterine smooth muscle possess ATP-sensitive potassium channel
por: Vadzyuk, Olga B., et al.
Publicado: (2018)

ATP-sensitive inwardly rectifying potassium channel regulation of viral infections in honey bees
por: O’Neal, Scott T., et al.
Publicado: (2017)

The expression of ATP-sensitive potassium channels in human umbilical arteries with severe pre-eclampsia
por: Yin, Benlan, et al.
Publicado: (2021)

ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
por: Ahmadi, Shamseddin, et al.
Publicado: (2014)

ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats
por: Alvin, Zikiar V., et al.
Publicado: (2011)

Curcumin inhibits proliferation of gastric cancer cells by impairing ATP-sensitive potassium channel opening
por: Liu, Xiaohong, et al.
Publicado: (2014)

Sarcolemmal ATP-sensitive potassium channel protects cardiac myocytes against lipopolysaccharide-induced apoptosis
por: Zhang, Xiaohui, et al.
Publicado: (2016)

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels
por: Wu, Jing-Xiang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ug1oic1ji7boo4bsqc791eig28