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The Dermatan Sulfate Proteoglycan Decorin Modulates α2β1 Integrin and the Vimentin Intermediate Filament System during Collagen Synthesis
Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterized by delayed wound healing. Decorin-null (Dcn(−/−)...
Autores principales: | Jungmann, Oliver, Nikolovska, Katerina, Stock, Christian, Schulz, Jan-Niklas, Eckes, Beate, Riethmüller, Christoph, Owens, Rick T., Iozzo, Renato V., Seidler, Daniela G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513320/ https://www.ncbi.nlm.nih.gov/pubmed/23226541 http://dx.doi.org/10.1371/journal.pone.0050809 |
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