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Overlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report

Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both autoimmune cholestatic liver disease and the association of these two conditions in the same patient is very rare. We report the case of a female patient presenting with a cholestatic liver disease and a panel of autoa...

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Autores principales: Oliveira, Elze Maria Gomes, Oliveira, Patricia Marinho, Becker, Vitoria, Dellavance, Alessandra, Andrade, Luis Eduardo Coelho, Lanzoni, Valeria, Silva, Antonio Eduardo Benedito, Ferraz, Maria Lucia Gomes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513426/
https://www.ncbi.nlm.nih.gov/pubmed/23226177
http://dx.doi.org/10.4021/jocmr1060w
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author Oliveira, Elze Maria Gomes
Oliveira, Patricia Marinho
Becker, Vitoria
Dellavance, Alessandra
Andrade, Luis Eduardo Coelho
Lanzoni, Valeria
Silva, Antonio Eduardo Benedito
Ferraz, Maria Lucia Gomes
author_facet Oliveira, Elze Maria Gomes
Oliveira, Patricia Marinho
Becker, Vitoria
Dellavance, Alessandra
Andrade, Luis Eduardo Coelho
Lanzoni, Valeria
Silva, Antonio Eduardo Benedito
Ferraz, Maria Lucia Gomes
author_sort Oliveira, Elze Maria Gomes
collection PubMed
description Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both autoimmune cholestatic liver disease and the association of these two conditions in the same patient is very rare. We report the case of a female patient presenting with a cholestatic liver disease and a panel of autoantibodies specific for PBC, including antibodies to mitochondrial E2-pyruvate dehydrogenase, gp-210 and Sp-100. Beside these findings, the liver biopsy revealed concentric fibrosis of small biliary ducts and the magnetic resonance cholangiography presented no abnormal findings. Diagnosis of small duct PSC/PBC overlapping was done. No description of this association was found in the literature. Clinical and serological features of this unusual finding are discussed.
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spelling pubmed-35134262012-12-05 Overlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report Oliveira, Elze Maria Gomes Oliveira, Patricia Marinho Becker, Vitoria Dellavance, Alessandra Andrade, Luis Eduardo Coelho Lanzoni, Valeria Silva, Antonio Eduardo Benedito Ferraz, Maria Lucia Gomes J Clin Med Res Case Report Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both autoimmune cholestatic liver disease and the association of these two conditions in the same patient is very rare. We report the case of a female patient presenting with a cholestatic liver disease and a panel of autoantibodies specific for PBC, including antibodies to mitochondrial E2-pyruvate dehydrogenase, gp-210 and Sp-100. Beside these findings, the liver biopsy revealed concentric fibrosis of small biliary ducts and the magnetic resonance cholangiography presented no abnormal findings. Diagnosis of small duct PSC/PBC overlapping was done. No description of this association was found in the literature. Clinical and serological features of this unusual finding are discussed. Elmer Press 2012-12 2012-11-11 /pmc/articles/PMC3513426/ /pubmed/23226177 http://dx.doi.org/10.4021/jocmr1060w Text en Copyright 2012, Oliveira et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Oliveira, Elze Maria Gomes
Oliveira, Patricia Marinho
Becker, Vitoria
Dellavance, Alessandra
Andrade, Luis Eduardo Coelho
Lanzoni, Valeria
Silva, Antonio Eduardo Benedito
Ferraz, Maria Lucia Gomes
Overlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report
title Overlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report
title_full Overlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report
title_fullStr Overlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report
title_full_unstemmed Overlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report
title_short Overlapping of Primary Biliary Cirrhosis and Small Duct Primary Sclerosing Cholangitis: First Case Report
title_sort overlapping of primary biliary cirrhosis and small duct primary sclerosing cholangitis: first case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513426/
https://www.ncbi.nlm.nih.gov/pubmed/23226177
http://dx.doi.org/10.4021/jocmr1060w
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