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Translational animal models of autism and neurodevelopmental disorders

Autism is a neurodevelopmental disorder whose diagnosis is based on three behavioral criteria: unusual reciprocal social interactions, deficits in communication, and stereotyped repetitive behaviors with restricted interests. A large number of de novo single gene mutations and chromosomal deletions...

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Detalles Bibliográficos
Autor principal: Crawley, Jacqueline N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513683/
https://www.ncbi.nlm.nih.gov/pubmed/23226954
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author Crawley, Jacqueline N.
author_facet Crawley, Jacqueline N.
author_sort Crawley, Jacqueline N.
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description Autism is a neurodevelopmental disorder whose diagnosis is based on three behavioral criteria: unusual reciprocal social interactions, deficits in communication, and stereotyped repetitive behaviors with restricted interests. A large number of de novo single gene mutations and chromosomal deletions are associated with autism spectrum disorders. Based on the strong genetic evidence, mice with targeted mutations in homologous genes have been generated as translational research tools. Mouse models of autism have revealed behavioral and biological outcomes of mutations in risk genes. The field is now poised to employ the most robust phenotypes in the most replicable mouse models for preclinical screening of novel therapeutics.
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spelling pubmed-35136832012-12-07 Translational animal models of autism and neurodevelopmental disorders Crawley, Jacqueline N. Dialogues Clin Neurosci Clinical Research Autism is a neurodevelopmental disorder whose diagnosis is based on three behavioral criteria: unusual reciprocal social interactions, deficits in communication, and stereotyped repetitive behaviors with restricted interests. A large number of de novo single gene mutations and chromosomal deletions are associated with autism spectrum disorders. Based on the strong genetic evidence, mice with targeted mutations in homologous genes have been generated as translational research tools. Mouse models of autism have revealed behavioral and biological outcomes of mutations in risk genes. The field is now poised to employ the most robust phenotypes in the most replicable mouse models for preclinical screening of novel therapeutics. Les Laboratoires Servier 2012-09 /pmc/articles/PMC3513683/ /pubmed/23226954 Text en Copyright: © 2012 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Crawley, Jacqueline N.
Translational animal models of autism and neurodevelopmental disorders
title Translational animal models of autism and neurodevelopmental disorders
title_full Translational animal models of autism and neurodevelopmental disorders
title_fullStr Translational animal models of autism and neurodevelopmental disorders
title_full_unstemmed Translational animal models of autism and neurodevelopmental disorders
title_short Translational animal models of autism and neurodevelopmental disorders
title_sort translational animal models of autism and neurodevelopmental disorders
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513683/
https://www.ncbi.nlm.nih.gov/pubmed/23226954
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