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SCAR knockouts in Dictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods

Under normal conditions, the Arp2/3 complex activator SCAR/WAVE controls actin polymerization in pseudopods, whereas Wiskott–Aldrich syndrome protein (WASP) assembles actin at clathrin-coated pits. We show that, unexpectedly, Dictyostelium discoideum SCAR knockouts could still spread, migrate, and c...

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Detalles Bibliográficos
Autores principales:	Veltman, Douwe M., King, Jason S., Machesky, Laura M., Insall, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514037/ https://www.ncbi.nlm.nih.gov/pubmed/22891261 http://dx.doi.org/10.1083/jcb.201205058

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