The role of BCL11B in hematological malignancy

The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignanc...

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Detalles Bibliográficos
Autores principales: Huang, Xin, Du, Xin, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514087/
https://www.ncbi.nlm.nih.gov/pubmed/23211040
http://dx.doi.org/10.1186/2162-3619-1-22
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author Huang, Xin
Du, Xin
Li, Yangqiu
author_facet Huang, Xin
Du, Xin
Li, Yangqiu
author_sort Huang, Xin
collection PubMed
description The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignancies. Remarkably, the BCL11B gene is responsible for the regulation of the apoptotic process and cell proliferation. This review summarizes current data and knowledge concerning the alteration of BCL11B in hematological malignancies and its role as a potential target for therapies directed against T cell malignancies.
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spelling pubmed-35140872012-12-05 The role of BCL11B in hematological malignancy Huang, Xin Du, Xin Li, Yangqiu Exp Hematol Oncol Review The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignancies. Remarkably, the BCL11B gene is responsible for the regulation of the apoptotic process and cell proliferation. This review summarizes current data and knowledge concerning the alteration of BCL11B in hematological malignancies and its role as a potential target for therapies directed against T cell malignancies. BioMed Central 2012-08-22 /pmc/articles/PMC3514087/ /pubmed/23211040 http://dx.doi.org/10.1186/2162-3619-1-22 Text en Copyright ©2012 Huang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Huang, Xin
Du, Xin
Li, Yangqiu
The role of BCL11B in hematological malignancy
title The role of BCL11B in hematological malignancy
title_full The role of BCL11B in hematological malignancy
title_fullStr The role of BCL11B in hematological malignancy
title_full_unstemmed The role of BCL11B in hematological malignancy
title_short The role of BCL11B in hematological malignancy
title_sort role of bcl11b in hematological malignancy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514087/
https://www.ncbi.nlm.nih.gov/pubmed/23211040
http://dx.doi.org/10.1186/2162-3619-1-22
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