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RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing

Amyloid-β-protein (Aβ), the key component of senile plaques in Alzheimer's disease (AD) brain, is produced from amyloid precursor protein (APP) by cleavage of β-secretase and then γ-secretase. APP adaptor proteins with phosphotyrosine-binding (PTB) domains, including Dab (gene: DAB) and Numb (g...

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Detalles Bibliográficos
Autores principales:	Xie, Zhongcong, Dong, Yuanlin, Maeda, Uta, Xia, Weiming, Tanzi, Rudolph E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514095/ https://www.ncbi.nlm.nih.gov/pubmed/23211096 http://dx.doi.org/10.1186/2047-9158-1-8

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