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Current management and prognostic features for gastrointestinal stromal tumor (GIST)

Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST) account for approximately 1% to 3% of all malignant...

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Autores principales: Lamba, Gurpreet, Gupta, Ridhi, Lee, Byung, Ambrale, Samir, Liu, Delong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514103/
https://www.ncbi.nlm.nih.gov/pubmed/23210689
http://dx.doi.org/10.1186/2162-3619-1-14
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author Lamba, Gurpreet
Gupta, Ridhi
Lee, Byung
Ambrale, Samir
Liu, Delong
author_facet Lamba, Gurpreet
Gupta, Ridhi
Lee, Byung
Ambrale, Samir
Liu, Delong
author_sort Lamba, Gurpreet
collection PubMed
description Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST) account for approximately 1% to 3% of all malignant GI tumors. The clinical features can vary depending on the anatomic location, size and aggressiveness of the tumor. Metastatic GIST represents a successful example of molecular targeted therapy. In this comprehensive review, we discuss the epidemiology, clinical features and diagnostic modalities for GIST. We also describe treatment options for early stage, locally advanced and metastatic GIST. Indications for neoadjuvant and adjuvant therapy along with duration of therapy are also explained. A brief discussion of latest biomarkers and updates from recent meetings is also provided.
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spelling pubmed-35141032012-12-05 Current management and prognostic features for gastrointestinal stromal tumor (GIST) Lamba, Gurpreet Gupta, Ridhi Lee, Byung Ambrale, Samir Liu, Delong Exp Hematol Oncol Review Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST) account for approximately 1% to 3% of all malignant GI tumors. The clinical features can vary depending on the anatomic location, size and aggressiveness of the tumor. Metastatic GIST represents a successful example of molecular targeted therapy. In this comprehensive review, we discuss the epidemiology, clinical features and diagnostic modalities for GIST. We also describe treatment options for early stage, locally advanced and metastatic GIST. Indications for neoadjuvant and adjuvant therapy along with duration of therapy are also explained. A brief discussion of latest biomarkers and updates from recent meetings is also provided. BioMed Central 2012-06-18 /pmc/articles/PMC3514103/ /pubmed/23210689 http://dx.doi.org/10.1186/2162-3619-1-14 Text en Copyright ©2012 Lamba et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lamba, Gurpreet
Gupta, Ridhi
Lee, Byung
Ambrale, Samir
Liu, Delong
Current management and prognostic features for gastrointestinal stromal tumor (GIST)
title Current management and prognostic features for gastrointestinal stromal tumor (GIST)
title_full Current management and prognostic features for gastrointestinal stromal tumor (GIST)
title_fullStr Current management and prognostic features for gastrointestinal stromal tumor (GIST)
title_full_unstemmed Current management and prognostic features for gastrointestinal stromal tumor (GIST)
title_short Current management and prognostic features for gastrointestinal stromal tumor (GIST)
title_sort current management and prognostic features for gastrointestinal stromal tumor (gist)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514103/
https://www.ncbi.nlm.nih.gov/pubmed/23210689
http://dx.doi.org/10.1186/2162-3619-1-14
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