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Current management and prognostic features for gastrointestinal stromal tumor (GIST)
Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST) account for approximately 1% to 3% of all malignant...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514103/ https://www.ncbi.nlm.nih.gov/pubmed/23210689 http://dx.doi.org/10.1186/2162-3619-1-14 |
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author | Lamba, Gurpreet Gupta, Ridhi Lee, Byung Ambrale, Samir Liu, Delong |
author_facet | Lamba, Gurpreet Gupta, Ridhi Lee, Byung Ambrale, Samir Liu, Delong |
author_sort | Lamba, Gurpreet |
collection | PubMed |
description | Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST) account for approximately 1% to 3% of all malignant GI tumors. The clinical features can vary depending on the anatomic location, size and aggressiveness of the tumor. Metastatic GIST represents a successful example of molecular targeted therapy. In this comprehensive review, we discuss the epidemiology, clinical features and diagnostic modalities for GIST. We also describe treatment options for early stage, locally advanced and metastatic GIST. Indications for neoadjuvant and adjuvant therapy along with duration of therapy are also explained. A brief discussion of latest biomarkers and updates from recent meetings is also provided. |
format | Online Article Text |
id | pubmed-3514103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35141032012-12-05 Current management and prognostic features for gastrointestinal stromal tumor (GIST) Lamba, Gurpreet Gupta, Ridhi Lee, Byung Ambrale, Samir Liu, Delong Exp Hematol Oncol Review Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST) account for approximately 1% to 3% of all malignant GI tumors. The clinical features can vary depending on the anatomic location, size and aggressiveness of the tumor. Metastatic GIST represents a successful example of molecular targeted therapy. In this comprehensive review, we discuss the epidemiology, clinical features and diagnostic modalities for GIST. We also describe treatment options for early stage, locally advanced and metastatic GIST. Indications for neoadjuvant and adjuvant therapy along with duration of therapy are also explained. A brief discussion of latest biomarkers and updates from recent meetings is also provided. BioMed Central 2012-06-18 /pmc/articles/PMC3514103/ /pubmed/23210689 http://dx.doi.org/10.1186/2162-3619-1-14 Text en Copyright ©2012 Lamba et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lamba, Gurpreet Gupta, Ridhi Lee, Byung Ambrale, Samir Liu, Delong Current management and prognostic features for gastrointestinal stromal tumor (GIST) |
title | Current management and prognostic features for gastrointestinal stromal tumor (GIST) |
title_full | Current management and prognostic features for gastrointestinal stromal tumor (GIST) |
title_fullStr | Current management and prognostic features for gastrointestinal stromal tumor (GIST) |
title_full_unstemmed | Current management and prognostic features for gastrointestinal stromal tumor (GIST) |
title_short | Current management and prognostic features for gastrointestinal stromal tumor (GIST) |
title_sort | current management and prognostic features for gastrointestinal stromal tumor (gist) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514103/ https://www.ncbi.nlm.nih.gov/pubmed/23210689 http://dx.doi.org/10.1186/2162-3619-1-14 |
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