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Premotor biomarkers for Parkinson's disease - a promising direction of research
The second most serious neurodegenerative disease is Parkinson’s disease (PD). Over the past several decades, a strong body of evidence suggests that PD can begin years before the hallmark clinical motor symptoms appear. Biomarkers for PD are urgently needed to differentiate between neurodegenerativ...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514104/ https://www.ncbi.nlm.nih.gov/pubmed/23211054 http://dx.doi.org/10.1186/2047-9158-1-11 |
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author | Haas, Brian R Stewart, Tessandra H Zhang, Jing |
author_facet | Haas, Brian R Stewart, Tessandra H Zhang, Jing |
author_sort | Haas, Brian R |
collection | PubMed |
description | The second most serious neurodegenerative disease is Parkinson’s disease (PD). Over the past several decades, a strong body of evidence suggests that PD can begin years before the hallmark clinical motor symptoms appear. Biomarkers for PD are urgently needed to differentiate between neurodegenerative disorders, screen novel therapeutics, and predict eventual clinical PD before the onset of symptoms. Some clinical evaluations and neuroimaging techniques have been developed in the last several years with some success in this area. Moreover, other strategies have been utilized to identify biochemical and genetic markers associated with PD leading to the examination of PD progression and pathogenesis in cerebrospinal fluid, blood, or saliva. Finally, interesting results are surfacing from preliminary studies using known PD-associated genetic mutations to assess potential premotor PD biomarkers. The current review highlights recent advances and underscores areas of potential advancement. |
format | Online Article Text |
id | pubmed-3514104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35141042012-12-05 Premotor biomarkers for Parkinson's disease - a promising direction of research Haas, Brian R Stewart, Tessandra H Zhang, Jing Transl Neurodegener Review The second most serious neurodegenerative disease is Parkinson’s disease (PD). Over the past several decades, a strong body of evidence suggests that PD can begin years before the hallmark clinical motor symptoms appear. Biomarkers for PD are urgently needed to differentiate between neurodegenerative disorders, screen novel therapeutics, and predict eventual clinical PD before the onset of symptoms. Some clinical evaluations and neuroimaging techniques have been developed in the last several years with some success in this area. Moreover, other strategies have been utilized to identify biochemical and genetic markers associated with PD leading to the examination of PD progression and pathogenesis in cerebrospinal fluid, blood, or saliva. Finally, interesting results are surfacing from preliminary studies using known PD-associated genetic mutations to assess potential premotor PD biomarkers. The current review highlights recent advances and underscores areas of potential advancement. BioMed Central 2012-05-31 /pmc/articles/PMC3514104/ /pubmed/23211054 http://dx.doi.org/10.1186/2047-9158-1-11 Text en Copyright ©2012 Haas et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Haas, Brian R Stewart, Tessandra H Zhang, Jing Premotor biomarkers for Parkinson's disease - a promising direction of research |
title | Premotor biomarkers for Parkinson's disease - a promising direction of research |
title_full | Premotor biomarkers for Parkinson's disease - a promising direction of research |
title_fullStr | Premotor biomarkers for Parkinson's disease - a promising direction of research |
title_full_unstemmed | Premotor biomarkers for Parkinson's disease - a promising direction of research |
title_short | Premotor biomarkers for Parkinson's disease - a promising direction of research |
title_sort | premotor biomarkers for parkinson's disease - a promising direction of research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514104/ https://www.ncbi.nlm.nih.gov/pubmed/23211054 http://dx.doi.org/10.1186/2047-9158-1-11 |
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