Combination Therapy with Gossypol Reveals Synergism against Gemcitabine Resistance in Cancer Cells with High BCL-2 Expression

Although gemcitabine is highly active in several cancer types, intrinsic and acquired drug resistance remains a major challenge. Overexpression of Bcl-2 has been associated with gemcitabine resistance. The aim of this study is to determine whether gossypol can overcome gemcitabine resistance in cell...

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Detalles Bibliográficos
Autores principales: Wong, Foong Ying, Liem, Natalia, Xie, Chen, Yan, Fui Leng, Wong, Wing Cheong, Wang, Lingzhi, Yong, Wei-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514173/
https://www.ncbi.nlm.nih.gov/pubmed/23226540
http://dx.doi.org/10.1371/journal.pone.0050786

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