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HSULF-1 inhibits ERK and AKT signaling and decreases cell viability in vitro in human lung epithelial cells

BACKGROUND: Heparan sulfate proteoglycans (HSPGs) modulate the binding and activation of signaling pathways of specific growth factors, such as fibroblast growth factor-2 (FGF-2). Human endosulfatase 1 (HSULF-1) is an enzyme that selectively removes 6-O sulfate groups from HS side chains and alter t...

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Detalles Bibliográficos
Autores principales:	Zhang, Huiying, Newman, Donna R, Sannes, Philip L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514195/ https://www.ncbi.nlm.nih.gov/pubmed/22873647 http://dx.doi.org/10.1186/1465-9921-13-69

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