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The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 ubiquitin ligase, Highwire (Hiw), as an important regulator of axonal and synaptic degeneration. Mutations in hiw strongly...

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Detalles Bibliográficos
Autores principales:	Xiong, Xin, Hao, Yan, Sun, Kan, Li, Jiaxing, Li, Xia, Mishra, Bibhudatta, Soppina, Pushpanjali, Wu, Chunlai, Hume, Richard I., Collins, Catherine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514318/ https://www.ncbi.nlm.nih.gov/pubmed/23226106 http://dx.doi.org/10.1371/journal.pbio.1001440

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