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Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report

INTRODUCTION: Tumor-induced osteomalacia is a paraneoplastic syndrome of hypophosphatemia. Osteomalacia causes multiple bone fractures and severe pain. CASE PRESENTATION: We report the case of a 57-year-old Japanese man with tumor-induced osteomalacia associated with a middle cranial fossa bone tumo...

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Detalles Bibliográficos
Autores principales: Chokyu, Isao, Ishibashi, Kenichi, Goto, Takeo, Ohata, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514377/
https://www.ncbi.nlm.nih.gov/pubmed/22747833
http://dx.doi.org/10.1186/1752-1947-6-181
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author Chokyu, Isao
Ishibashi, Kenichi
Goto, Takeo
Ohata, Kenji
author_facet Chokyu, Isao
Ishibashi, Kenichi
Goto, Takeo
Ohata, Kenji
author_sort Chokyu, Isao
collection PubMed
description INTRODUCTION: Tumor-induced osteomalacia is a paraneoplastic syndrome of hypophosphatemia. Osteomalacia causes multiple bone fractures and severe pain. CASE PRESENTATION: We report the case of a 57-year-old Japanese man with tumor-induced osteomalacia associated with a middle cranial fossa bone tumor. The tumor was successfully resected by using a middle fossa epidural approach. His phosphate level recovered to a normal range immediately after the surgery. CONCLUSIONS: It is rare that tumor-induced osteomalacia originates from the middle skull base. This report suggests that, if patients have a clinical and biochemical picture suggestive of tumor-induced osteomalacia, it is crucial to perform a meticulous examination to detect the tumor or the lesion responsible for the tumor. The serum level of fibroblast growth factor 23 is the most reliable marker for evaluating the treatment outcome of tumor-induced osteomalacia.
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spelling pubmed-35143772012-12-05 Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report Chokyu, Isao Ishibashi, Kenichi Goto, Takeo Ohata, Kenji J Med Case Rep Case Report INTRODUCTION: Tumor-induced osteomalacia is a paraneoplastic syndrome of hypophosphatemia. Osteomalacia causes multiple bone fractures and severe pain. CASE PRESENTATION: We report the case of a 57-year-old Japanese man with tumor-induced osteomalacia associated with a middle cranial fossa bone tumor. The tumor was successfully resected by using a middle fossa epidural approach. His phosphate level recovered to a normal range immediately after the surgery. CONCLUSIONS: It is rare that tumor-induced osteomalacia originates from the middle skull base. This report suggests that, if patients have a clinical and biochemical picture suggestive of tumor-induced osteomalacia, it is crucial to perform a meticulous examination to detect the tumor or the lesion responsible for the tumor. The serum level of fibroblast growth factor 23 is the most reliable marker for evaluating the treatment outcome of tumor-induced osteomalacia. BioMed Central 2012-07-02 /pmc/articles/PMC3514377/ /pubmed/22747833 http://dx.doi.org/10.1186/1752-1947-6-181 Text en Copyright ©2012 Chokyu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chokyu, Isao
Ishibashi, Kenichi
Goto, Takeo
Ohata, Kenji
Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report
title Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report
title_full Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report
title_fullStr Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report
title_full_unstemmed Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report
title_short Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report
title_sort oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514377/
https://www.ncbi.nlm.nih.gov/pubmed/22747833
http://dx.doi.org/10.1186/1752-1947-6-181
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