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Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers

BACKGROUND: Infectious diseases in plants, animals and humans are often transmitted indirectly between hosts (or between groups of hosts), i.e. via some route through the environment instead of via direct contacts between these hosts. Here we study indirect transmission experimentally, using transmi...

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Autores principales: van Bunnik, Bram AD, Hagenaars, Thomas J, Bolder, Nico M, Nodelijk, Gonnie, de Jong, Mart CM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514386/
https://www.ncbi.nlm.nih.gov/pubmed/22831274
http://dx.doi.org/10.1186/1746-6148-8-123
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author van Bunnik, Bram AD
Hagenaars, Thomas J
Bolder, Nico M
Nodelijk, Gonnie
de Jong, Mart CM
author_facet van Bunnik, Bram AD
Hagenaars, Thomas J
Bolder, Nico M
Nodelijk, Gonnie
de Jong, Mart CM
author_sort van Bunnik, Bram AD
collection PubMed
description BACKGROUND: Infectious diseases in plants, animals and humans are often transmitted indirectly between hosts (or between groups of hosts), i.e. via some route through the environment instead of via direct contacts between these hosts. Here we study indirect transmission experimentally, using transmission of Campylobacter jejuni (C. jejuni) between spatially separated broilers as a model system. We distinguish three stages in the process of indirect transmission; (1) an infectious “sender” excretes the agent, after which (2) the agent is transported via some route to a susceptible “receiver”, and subsequently (3) the receiver becomes colonised by the agent. The role of the sender and receiver side (stage 1 and stage 3) was studied here by using acidification of the drinking water as a modulation mechanism. RESULTS: In the experiment one control group and three treatment groups were monitored for the presence of C. jejuni by taking daily cloacal swabs. The three treatments consisted of acidification of the drinking water of the inoculated animals (the senders), acidification of the drinking water of the susceptible animals (the receivers) or acidification of the drinking water of both inoculated and susceptible animals. In the control group 12 animals got colonised out of a possible 40, in each treatment groups 3 animals out of a possible 40 were found colonised with C. jejuni. CONCLUSIONS: The results of the experiments show a significant decrease in transmission rate (β) between the control groups and treatment groups (p < 0.01 for all groups) but not between different treatments; there is a significant negative interaction effect when both the sender and the receiver group receive acidified drinking water (p = 0.01). This negative interaction effect could be due to selection of bacteria already at the sender side thereby diminishing the effect of acidification at the receiver side.
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spelling pubmed-35143862012-12-06 Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers van Bunnik, Bram AD Hagenaars, Thomas J Bolder, Nico M Nodelijk, Gonnie de Jong, Mart CM BMC Vet Res Research Article BACKGROUND: Infectious diseases in plants, animals and humans are often transmitted indirectly between hosts (or between groups of hosts), i.e. via some route through the environment instead of via direct contacts between these hosts. Here we study indirect transmission experimentally, using transmission of Campylobacter jejuni (C. jejuni) between spatially separated broilers as a model system. We distinguish three stages in the process of indirect transmission; (1) an infectious “sender” excretes the agent, after which (2) the agent is transported via some route to a susceptible “receiver”, and subsequently (3) the receiver becomes colonised by the agent. The role of the sender and receiver side (stage 1 and stage 3) was studied here by using acidification of the drinking water as a modulation mechanism. RESULTS: In the experiment one control group and three treatment groups were monitored for the presence of C. jejuni by taking daily cloacal swabs. The three treatments consisted of acidification of the drinking water of the inoculated animals (the senders), acidification of the drinking water of the susceptible animals (the receivers) or acidification of the drinking water of both inoculated and susceptible animals. In the control group 12 animals got colonised out of a possible 40, in each treatment groups 3 animals out of a possible 40 were found colonised with C. jejuni. CONCLUSIONS: The results of the experiments show a significant decrease in transmission rate (β) between the control groups and treatment groups (p < 0.01 for all groups) but not between different treatments; there is a significant negative interaction effect when both the sender and the receiver group receive acidified drinking water (p = 0.01). This negative interaction effect could be due to selection of bacteria already at the sender side thereby diminishing the effect of acidification at the receiver side. BioMed Central 2012-07-25 /pmc/articles/PMC3514386/ /pubmed/22831274 http://dx.doi.org/10.1186/1746-6148-8-123 Text en Copyright ©2012 van Bunnik et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
van Bunnik, Bram AD
Hagenaars, Thomas J
Bolder, Nico M
Nodelijk, Gonnie
de Jong, Mart CM
Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers
title Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers
title_full Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers
title_fullStr Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers
title_full_unstemmed Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers
title_short Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers
title_sort interaction effects between sender and receiver processes in indirect transmission of campylobacter jejuni between broilers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514386/
https://www.ncbi.nlm.nih.gov/pubmed/22831274
http://dx.doi.org/10.1186/1746-6148-8-123
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