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P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia

Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to dementia. Methods currently available to identify risk for conversion do not combine enough sensitivity and specificity, which is even more problematic in low-educated populations. Current guidelines suggest...

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Autores principales: Parra, Mario A., Ascencio, Lindsay Lorena, Urquina, Hugo Fenando, Manes, Facundo, Ibáñez, Agustín M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514532/
https://www.ncbi.nlm.nih.gov/pubmed/23227021
http://dx.doi.org/10.3389/fneur.2012.00172
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author Parra, Mario A.
Ascencio, Lindsay Lorena
Urquina, Hugo Fenando
Manes, Facundo
Ibáñez, Agustín M.
author_facet Parra, Mario A.
Ascencio, Lindsay Lorena
Urquina, Hugo Fenando
Manes, Facundo
Ibáñez, Agustín M.
author_sort Parra, Mario A.
collection PubMed
description Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to dementia. Methods currently available to identify risk for conversion do not combine enough sensitivity and specificity, which is even more problematic in low-educated populations. Current guidelines suggest the use of combined markers for dementia to enhance the prediction accuracy of assessment methods. The present study adhered to this proposal and investigated the sensitivity and specificity of the electrophysiological component P300 and standard neuropsychological tests to assess patients with Alzheimer’s disease (AD) and MCI recruited from a low-income country. The neuropsychological battery comprised tests of memory, attention, language, praxis, and executive functions. The P300 was recorded using a classical visual odd-ball paradigm. Three variables were found to achieve sensitivity and specificity values above 80% (Immediate and Delayed recall of word list – CERAD – and the latency of P300) for both MCI and AD. When they entered the model together (i.e., combined approach) the sensitivity for MCI increased to 96% and the specificity remained high (80%). Our preliminary findings suggest that the combined use of sensitive neuropsychological tasks and the analysis of the P300 may offer a very useful method for the preclinical assessment of AD, particularly in populations with low socioeconomic and educational levels. Our results provide a platform and justification to employ more resources to convert P300 and related parameters into a biological marker for AD.
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spelling pubmed-35145322012-12-07 P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia Parra, Mario A. Ascencio, Lindsay Lorena Urquina, Hugo Fenando Manes, Facundo Ibáñez, Agustín M. Front Neurol Neuroscience Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to dementia. Methods currently available to identify risk for conversion do not combine enough sensitivity and specificity, which is even more problematic in low-educated populations. Current guidelines suggest the use of combined markers for dementia to enhance the prediction accuracy of assessment methods. The present study adhered to this proposal and investigated the sensitivity and specificity of the electrophysiological component P300 and standard neuropsychological tests to assess patients with Alzheimer’s disease (AD) and MCI recruited from a low-income country. The neuropsychological battery comprised tests of memory, attention, language, praxis, and executive functions. The P300 was recorded using a classical visual odd-ball paradigm. Three variables were found to achieve sensitivity and specificity values above 80% (Immediate and Delayed recall of word list – CERAD – and the latency of P300) for both MCI and AD. When they entered the model together (i.e., combined approach) the sensitivity for MCI increased to 96% and the specificity remained high (80%). Our preliminary findings suggest that the combined use of sensitive neuropsychological tasks and the analysis of the P300 may offer a very useful method for the preclinical assessment of AD, particularly in populations with low socioeconomic and educational levels. Our results provide a platform and justification to employ more resources to convert P300 and related parameters into a biological marker for AD. Frontiers Media S.A. 2012-12-05 /pmc/articles/PMC3514532/ /pubmed/23227021 http://dx.doi.org/10.3389/fneur.2012.00172 Text en Copyright © 2012 Parra, Ascencio, Urquina, Manes and Ibáñez. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Parra, Mario A.
Ascencio, Lindsay Lorena
Urquina, Hugo Fenando
Manes, Facundo
Ibáñez, Agustín M.
P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia
title P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia
title_full P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia
title_fullStr P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia
title_full_unstemmed P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia
title_short P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia
title_sort p300 and neuropsychological assessment in mild cognitive impairment and alzheimer dementia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514532/
https://www.ncbi.nlm.nih.gov/pubmed/23227021
http://dx.doi.org/10.3389/fneur.2012.00172
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