A heterozygous IDH1(R132H/WT) mutation induces genome-wide alterations in DNA methylation

Monoallelic point mutations of the NADP(+)-dependent isocitrate dehydrogenases IDH1 and IDH2 occur frequently in gliomas, acute myeloid leukemias, and chondromas, and display robust association with specific DNA hypermethylation signatures. Here we show that heterozygous expression of the IDH1(R132H...

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Detalles Bibliográficos
Autores principales: Duncan, Christopher G., Barwick, Benjamin G., Jin, Genglin, Rago, Carlo, Kapoor-Vazirani, Priya, Powell, Doris R., Chi, Jen-Tsan, Bigner, Darell D., Vertino, Paula M., Yan, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514664/
https://www.ncbi.nlm.nih.gov/pubmed/22899282
http://dx.doi.org/10.1101/gr.132738.111

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