Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2

KCNE1 associates with KCNQ1 to increase its current amplitude and slow the activation gating process, creating the slow delayed rectifier channel that functions as a “repolarization reserve” in human heart. The transmembrane domain (TMD) of KCNE1 plays a key role in modulating KCNQ1 pore conductance...

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Detalles Bibliográficos
Autores principales: Wang, Yuhong, Zhang, Mei, Xu, Yu, Jiang, Min, Zankov, Dimitar P., Cui, Meng, Tseng, Gea-Ny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514736/
https://www.ncbi.nlm.nih.gov/pubmed/23183700
http://dx.doi.org/10.1085/jgp.201210847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514736/
https://www.ncbi.nlm.nih.gov/pubmed/23183700
http://dx.doi.org/10.1085/jgp.201210847

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