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Bone Sarcomas: From Biology to Targeted Therapies

Primary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare diseases which occur mainly in adolescents and young adults. With the current therapies, some patients remain very difficult to treat, such as tumour with poor histological response to preoperative CT (or large initial tumour...

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Autores principales: Gaspar, Nathalie, Di Giannatale, Angela, Geoerger, Birgit, Redini, Françoise, Corradini, Nadège, Enz-Werle, Natacha, Tirode, Franck, Marec-Berard, Perrine, Gentet, Jean-Claude, Laurence, Valérie, Piperno-Neumann, Sophie, Oberlin, Odile, Brugieres, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514839/
https://www.ncbi.nlm.nih.gov/pubmed/23226965
http://dx.doi.org/10.1155/2012/301975
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author Gaspar, Nathalie
Di Giannatale, Angela
Geoerger, Birgit
Redini, Françoise
Corradini, Nadège
Enz-Werle, Natacha
Tirode, Franck
Marec-Berard, Perrine
Gentet, Jean-Claude
Laurence, Valérie
Piperno-Neumann, Sophie
Oberlin, Odile
Brugieres, Laurence
author_facet Gaspar, Nathalie
Di Giannatale, Angela
Geoerger, Birgit
Redini, Françoise
Corradini, Nadège
Enz-Werle, Natacha
Tirode, Franck
Marec-Berard, Perrine
Gentet, Jean-Claude
Laurence, Valérie
Piperno-Neumann, Sophie
Oberlin, Odile
Brugieres, Laurence
author_sort Gaspar, Nathalie
collection PubMed
description Primary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare diseases which occur mainly in adolescents and young adults. With the current therapies, some patients remain very difficult to treat, such as tumour with poor histological response to preoperative CT (or large initial tumour volume for Ewing sarcomas not operated), patients with multiple metastases at or those who relapsed. In order to develop new therapies against these rare tumours, we need to unveil the key driving factors and molecular abnormalities behind the malignant characteristics and to broaden our understanding of the phenomena sustaining the metastatic phenotype and treatment resistance in these tumours. In this paper, starting with the biology of these tumours, we will discuss potential therapeutic targets aimed at increasing local tumour control, limiting metastatic spread, and finally improving patient survival.
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spelling pubmed-35148392012-12-07 Bone Sarcomas: From Biology to Targeted Therapies Gaspar, Nathalie Di Giannatale, Angela Geoerger, Birgit Redini, Françoise Corradini, Nadège Enz-Werle, Natacha Tirode, Franck Marec-Berard, Perrine Gentet, Jean-Claude Laurence, Valérie Piperno-Neumann, Sophie Oberlin, Odile Brugieres, Laurence Sarcoma Review Article Primary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare diseases which occur mainly in adolescents and young adults. With the current therapies, some patients remain very difficult to treat, such as tumour with poor histological response to preoperative CT (or large initial tumour volume for Ewing sarcomas not operated), patients with multiple metastases at or those who relapsed. In order to develop new therapies against these rare tumours, we need to unveil the key driving factors and molecular abnormalities behind the malignant characteristics and to broaden our understanding of the phenomena sustaining the metastatic phenotype and treatment resistance in these tumours. In this paper, starting with the biology of these tumours, we will discuss potential therapeutic targets aimed at increasing local tumour control, limiting metastatic spread, and finally improving patient survival. Hindawi Publishing Corporation 2012 2012-11-27 /pmc/articles/PMC3514839/ /pubmed/23226965 http://dx.doi.org/10.1155/2012/301975 Text en Copyright © 2012 Nathalie Gaspar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gaspar, Nathalie
Di Giannatale, Angela
Geoerger, Birgit
Redini, Françoise
Corradini, Nadège
Enz-Werle, Natacha
Tirode, Franck
Marec-Berard, Perrine
Gentet, Jean-Claude
Laurence, Valérie
Piperno-Neumann, Sophie
Oberlin, Odile
Brugieres, Laurence
Bone Sarcomas: From Biology to Targeted Therapies
title Bone Sarcomas: From Biology to Targeted Therapies
title_full Bone Sarcomas: From Biology to Targeted Therapies
title_fullStr Bone Sarcomas: From Biology to Targeted Therapies
title_full_unstemmed Bone Sarcomas: From Biology to Targeted Therapies
title_short Bone Sarcomas: From Biology to Targeted Therapies
title_sort bone sarcomas: from biology to targeted therapies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514839/
https://www.ncbi.nlm.nih.gov/pubmed/23226965
http://dx.doi.org/10.1155/2012/301975
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