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N,N′-bis­[(3-hy­droxy-4(4H)-oxypyran-2-yl)meth­yl]-N,N′-dimethyl­ethylene-1,2-diammonium tetra­chloridoplatinate(II) dihydrate

The title compound (C(16)H(22)N(2)O(6))[PtCl(4)]·2H(2)O, shows anti­proliferative activity in eight tumor cell lines. The asymmetric unit consists of one solvent water mol­ecule on a general position, and one half of each of the polyammonium cation and the tetrachloridoplatinate(II) anion, both of t...

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Detalles Bibliográficos
Autores principales: Fusi, Vieri, Giorgi, Luca, Macedi, Eleonora, Paoli, Paola, Rossi, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515092/
https://www.ncbi.nlm.nih.gov/pubmed/23284319
http://dx.doi.org/10.1107/S1600536812040949
Descripción
Sumario:The title compound (C(16)H(22)N(2)O(6))[PtCl(4)]·2H(2)O, shows anti­proliferative activity in eight tumor cell lines. The asymmetric unit consists of one solvent water mol­ecule on a general position, and one half of each of the polyammonium cation and the tetrachloridoplatinate(II) anion, both of them located on centers of inversion. In the crystal, the cations are connected via hydrogen bonding between the carbonyl O atoms and the hydroxyl H atoms into zigzag chains that elongate in the c-axis direction. In addition, the carbonyl O atom is hydrogen-bonded to the water mol­ecule which, in turn, inter­acts with the [PtCl(4)](2−) anion. Finally, the chains are linked by N—H(+)⋯Cl inter­actions into a three-dimensional network.