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N-[2-(5-Bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide

In the title compound, C(24)H(27)BrN(4)O(4)S(2), the mol­ecule is twisted at the sulfonyl S atom with a C—S(O(2))—N(H)—C torsion angle of 62.6 (3)°. The benzene rings bridged by the sulfonamide group are tilted to each other by a dihedral angle of 60.6 (1)°. The dihedral angle between the sulfur-bri...

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Autores principales: Kumar, Mohan, Mallesha, L., Sridhar, M. A., Kapoor, Kamini, Gupta, Vivek K., Kant, Rajni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515169/
https://www.ncbi.nlm.nih.gov/pubmed/23284396
http://dx.doi.org/10.1107/S1600536812040792
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author Kumar, Mohan
Mallesha, L.
Sridhar, M. A.
Kapoor, Kamini
Gupta, Vivek K.
Kant, Rajni
author_facet Kumar, Mohan
Mallesha, L.
Sridhar, M. A.
Kapoor, Kamini
Gupta, Vivek K.
Kant, Rajni
author_sort Kumar, Mohan
collection PubMed
description In the title compound, C(24)H(27)BrN(4)O(4)S(2), the mol­ecule is twisted at the sulfonyl S atom with a C—S(O(2))—N(H)—C torsion angle of 62.6 (3)°. The benzene rings bridged by the sulfonamide group are tilted to each other by a dihedral angle of 60.6 (1)°. The dihedral angle between the sulfur-bridged pyrimidine and benzene rings is 62.7 (1)°. The morpholine ring adopts a chair conformation. The mol­ecular conformation is stabilized by a weak intra­molecular π–π stacking inter­action between the pyrimidine and the 2,4,6-trimethyl­benzene rings [centroid–centroid distance = 3.793 (2) Å]. In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds into a chain along the b axis.
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spelling pubmed-35151692013-01-02 N-[2-(5-Bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide Kumar, Mohan Mallesha, L. Sridhar, M. A. Kapoor, Kamini Gupta, Vivek K. Kant, Rajni Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(24)H(27)BrN(4)O(4)S(2), the mol­ecule is twisted at the sulfonyl S atom with a C—S(O(2))—N(H)—C torsion angle of 62.6 (3)°. The benzene rings bridged by the sulfonamide group are tilted to each other by a dihedral angle of 60.6 (1)°. The dihedral angle between the sulfur-bridged pyrimidine and benzene rings is 62.7 (1)°. The morpholine ring adopts a chair conformation. The mol­ecular conformation is stabilized by a weak intra­molecular π–π stacking inter­action between the pyrimidine and the 2,4,6-trimethyl­benzene rings [centroid–centroid distance = 3.793 (2) Å]. In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds into a chain along the b axis. International Union of Crystallography 2012-10-03 /pmc/articles/PMC3515169/ /pubmed/23284396 http://dx.doi.org/10.1107/S1600536812040792 Text en © Kumar et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Kumar, Mohan
Mallesha, L.
Sridhar, M. A.
Kapoor, Kamini
Gupta, Vivek K.
Kant, Rajni
N-[2-(5-Bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide
title N-[2-(5-Bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide
title_full N-[2-(5-Bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide
title_fullStr N-[2-(5-Bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide
title_full_unstemmed N-[2-(5-Bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide
title_short N-[2-(5-Bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide
title_sort n-[2-(5-bromo-2-morpholin-4-ylpyrim­idin-4-ylsulfan­yl)-4-meth­oxy­phen­yl]-2,4,6-trimethyl­benzene­sulfonamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515169/
https://www.ncbi.nlm.nih.gov/pubmed/23284396
http://dx.doi.org/10.1107/S1600536812040792
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