10′-Chloro-3′,4′-dihydro-2′H-spiro­[cyclo­propane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one

In the title compound, C(14)H(13)ClN(2)O, the fused hydro­pyrimidine ring adopts an envelope conformation with one of the methyl­ene C atoms at the flap. The three-membered ring is approximately perpendicular to the attached isoquinoline ring system, with a dihedral angle of 89.44 (11)°. In the crys...

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Detalles Bibliográficos
Autores principales: Okuda, Kensuke, Hirota, Takashi, Nishina, Yuta, Ishida, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515329/
https://www.ncbi.nlm.nih.gov/pubmed/23284549
http://dx.doi.org/10.1107/S1600536812044261
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author Okuda, Kensuke
Hirota, Takashi
Nishina, Yuta
Ishida, Hiroyuki
author_facet Okuda, Kensuke
Hirota, Takashi
Nishina, Yuta
Ishida, Hiroyuki
author_sort Okuda, Kensuke
collection PubMed
description In the title compound, C(14)H(13)ClN(2)O, the fused hydro­pyrimidine ring adopts an envelope conformation with one of the methyl­ene C atoms at the flap. The three-membered ring is approximately perpendicular to the attached isoquinoline ring system, with a dihedral angle of 89.44 (11)°. In the crystal, mol­ecules are linked by a weak C—H⋯π inter­action, forming a helical chain along the c axis.
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spelling pubmed-35153292013-01-02 10′-Chloro-3′,4′-dihydro-2′H-spiro­[cyclo­propane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one Okuda, Kensuke Hirota, Takashi Nishina, Yuta Ishida, Hiroyuki Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(14)H(13)ClN(2)O, the fused hydro­pyrimidine ring adopts an envelope conformation with one of the methyl­ene C atoms at the flap. The three-membered ring is approximately perpendicular to the attached isoquinoline ring system, with a dihedral angle of 89.44 (11)°. In the crystal, mol­ecules are linked by a weak C—H⋯π inter­action, forming a helical chain along the c axis. International Union of Crystallography 2012-10-31 /pmc/articles/PMC3515329/ /pubmed/23284549 http://dx.doi.org/10.1107/S1600536812044261 Text en © Okuda et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Okuda, Kensuke
Hirota, Takashi
Nishina, Yuta
Ishida, Hiroyuki
10′-Chloro-3′,4′-dihydro-2′H-spiro­[cyclo­propane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one
title 10′-Chloro-3′,4′-dihydro-2′H-spiro­[cyclo­propane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one
title_full 10′-Chloro-3′,4′-dihydro-2′H-spiro­[cyclo­propane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one
title_fullStr 10′-Chloro-3′,4′-dihydro-2′H-spiro­[cyclo­propane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one
title_full_unstemmed 10′-Chloro-3′,4′-dihydro-2′H-spiro­[cyclo­propane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one
title_short 10′-Chloro-3′,4′-dihydro-2′H-spiro­[cyclo­propane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one
title_sort 10′-chloro-3′,4′-dihydro-2′h-spiro­[cyclo­propane-1,7′(6′h)-pyrimido[2,1-a]isoquinolin]-6′-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515329/
https://www.ncbi.nlm.nih.gov/pubmed/23284549
http://dx.doi.org/10.1107/S1600536812044261
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