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The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
BACKGROUND: Napsin A, an aspartic protease, is mainly expressed in alveolar type-II cells and renal proximal tubules and is a putative immunohistochemical marker for pulmonary adenocarcinomas. This study sought to determine whether napsin A could be measured in the serum to evaluate its relationship...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515468/ https://www.ncbi.nlm.nih.gov/pubmed/22963039 http://dx.doi.org/10.1186/1471-2466-12-55 |
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author | Samukawa, Takuya Hamada, Tsutomu Uto, Hirofumi Yanagi, Masakazu Tsukuya, Go Nosaki, Tsuyoshi Maeda, Masahiro Hirano, Takashi Tsubouchi, Hirohito Inoue, Hiromasa |
author_facet | Samukawa, Takuya Hamada, Tsutomu Uto, Hirofumi Yanagi, Masakazu Tsukuya, Go Nosaki, Tsuyoshi Maeda, Masahiro Hirano, Takashi Tsubouchi, Hirohito Inoue, Hiromasa |
author_sort | Samukawa, Takuya |
collection | PubMed |
description | BACKGROUND: Napsin A, an aspartic protease, is mainly expressed in alveolar type-II cells and renal proximal tubules and is a putative immunohistochemical marker for pulmonary adenocarcinomas. This study sought to determine whether napsin A could be measured in the serum to evaluate its relationship to idiopathic pulmonary fibrosis (IPF) and determine whether renal dysfunction might affect serum napsin A levels. METHODS: Serum levels of napsin A were measured in 20 patients with IPF, 34 patients with lung primary adenocarcinoma, 12 patients with kidney diseases, and 20 healthy volunteers. Surfactant protein (SP)-A, SP-D, and Krebs von den Lungen-6 (KL-6) levels in serum and pulmonary function tests were also evaluated in IPF patients. RESULTS: Circulating levels of napsin A were increased in patients with IPF, as compared with healthy controls, and they correlated with the severity of disease. Moreover, the serum napsin A levels were not elevated in patients with pulmonary adenocarcinoma or renal dysfunction. The distinguishing point between IPF and the controls was that the area under the receiver operating characteristic curve (ROC) of napsin A was larger than that of KL-6, SP-A, or SP-D. CONCLUSION: These findings suggest that serum napsin A may be a candidate biomarker for IPF. |
format | Online Article Text |
id | pubmed-3515468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35154682012-12-06 The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D Samukawa, Takuya Hamada, Tsutomu Uto, Hirofumi Yanagi, Masakazu Tsukuya, Go Nosaki, Tsuyoshi Maeda, Masahiro Hirano, Takashi Tsubouchi, Hirohito Inoue, Hiromasa BMC Pulm Med Research Article BACKGROUND: Napsin A, an aspartic protease, is mainly expressed in alveolar type-II cells and renal proximal tubules and is a putative immunohistochemical marker for pulmonary adenocarcinomas. This study sought to determine whether napsin A could be measured in the serum to evaluate its relationship to idiopathic pulmonary fibrosis (IPF) and determine whether renal dysfunction might affect serum napsin A levels. METHODS: Serum levels of napsin A were measured in 20 patients with IPF, 34 patients with lung primary adenocarcinoma, 12 patients with kidney diseases, and 20 healthy volunteers. Surfactant protein (SP)-A, SP-D, and Krebs von den Lungen-6 (KL-6) levels in serum and pulmonary function tests were also evaluated in IPF patients. RESULTS: Circulating levels of napsin A were increased in patients with IPF, as compared with healthy controls, and they correlated with the severity of disease. Moreover, the serum napsin A levels were not elevated in patients with pulmonary adenocarcinoma or renal dysfunction. The distinguishing point between IPF and the controls was that the area under the receiver operating characteristic curve (ROC) of napsin A was larger than that of KL-6, SP-A, or SP-D. CONCLUSION: These findings suggest that serum napsin A may be a candidate biomarker for IPF. BioMed Central 2012-09-11 /pmc/articles/PMC3515468/ /pubmed/22963039 http://dx.doi.org/10.1186/1471-2466-12-55 Text en Copyright ©2012 Samukawa et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Samukawa, Takuya Hamada, Tsutomu Uto, Hirofumi Yanagi, Masakazu Tsukuya, Go Nosaki, Tsuyoshi Maeda, Masahiro Hirano, Takashi Tsubouchi, Hirohito Inoue, Hiromasa The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D |
title | The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D |
title_full | The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D |
title_fullStr | The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D |
title_full_unstemmed | The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D |
title_short | The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D |
title_sort | elevation of serum napsin a in idiopathic pulmonary fibrosis, compared with kl-6, surfactant protein-a and surfactant protein-d |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515468/ https://www.ncbi.nlm.nih.gov/pubmed/22963039 http://dx.doi.org/10.1186/1471-2466-12-55 |
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