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The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D

BACKGROUND: Napsin A, an aspartic protease, is mainly expressed in alveolar type-II cells and renal proximal tubules and is a putative immunohistochemical marker for pulmonary adenocarcinomas. This study sought to determine whether napsin A could be measured in the serum to evaluate its relationship...

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Autores principales: Samukawa, Takuya, Hamada, Tsutomu, Uto, Hirofumi, Yanagi, Masakazu, Tsukuya, Go, Nosaki, Tsuyoshi, Maeda, Masahiro, Hirano, Takashi, Tsubouchi, Hirohito, Inoue, Hiromasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515468/
https://www.ncbi.nlm.nih.gov/pubmed/22963039
http://dx.doi.org/10.1186/1471-2466-12-55
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author Samukawa, Takuya
Hamada, Tsutomu
Uto, Hirofumi
Yanagi, Masakazu
Tsukuya, Go
Nosaki, Tsuyoshi
Maeda, Masahiro
Hirano, Takashi
Tsubouchi, Hirohito
Inoue, Hiromasa
author_facet Samukawa, Takuya
Hamada, Tsutomu
Uto, Hirofumi
Yanagi, Masakazu
Tsukuya, Go
Nosaki, Tsuyoshi
Maeda, Masahiro
Hirano, Takashi
Tsubouchi, Hirohito
Inoue, Hiromasa
author_sort Samukawa, Takuya
collection PubMed
description BACKGROUND: Napsin A, an aspartic protease, is mainly expressed in alveolar type-II cells and renal proximal tubules and is a putative immunohistochemical marker for pulmonary adenocarcinomas. This study sought to determine whether napsin A could be measured in the serum to evaluate its relationship to idiopathic pulmonary fibrosis (IPF) and determine whether renal dysfunction might affect serum napsin A levels. METHODS: Serum levels of napsin A were measured in 20 patients with IPF, 34 patients with lung primary adenocarcinoma, 12 patients with kidney diseases, and 20 healthy volunteers. Surfactant protein (SP)-A, SP-D, and Krebs von den Lungen-6 (KL-6) levels in serum and pulmonary function tests were also evaluated in IPF patients. RESULTS: Circulating levels of napsin A were increased in patients with IPF, as compared with healthy controls, and they correlated with the severity of disease. Moreover, the serum napsin A levels were not elevated in patients with pulmonary adenocarcinoma or renal dysfunction. The distinguishing point between IPF and the controls was that the area under the receiver operating characteristic curve (ROC) of napsin A was larger than that of KL-6, SP-A, or SP-D. CONCLUSION: These findings suggest that serum napsin A may be a candidate biomarker for IPF.
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spelling pubmed-35154682012-12-06 The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D Samukawa, Takuya Hamada, Tsutomu Uto, Hirofumi Yanagi, Masakazu Tsukuya, Go Nosaki, Tsuyoshi Maeda, Masahiro Hirano, Takashi Tsubouchi, Hirohito Inoue, Hiromasa BMC Pulm Med Research Article BACKGROUND: Napsin A, an aspartic protease, is mainly expressed in alveolar type-II cells and renal proximal tubules and is a putative immunohistochemical marker for pulmonary adenocarcinomas. This study sought to determine whether napsin A could be measured in the serum to evaluate its relationship to idiopathic pulmonary fibrosis (IPF) and determine whether renal dysfunction might affect serum napsin A levels. METHODS: Serum levels of napsin A were measured in 20 patients with IPF, 34 patients with lung primary adenocarcinoma, 12 patients with kidney diseases, and 20 healthy volunteers. Surfactant protein (SP)-A, SP-D, and Krebs von den Lungen-6 (KL-6) levels in serum and pulmonary function tests were also evaluated in IPF patients. RESULTS: Circulating levels of napsin A were increased in patients with IPF, as compared with healthy controls, and they correlated with the severity of disease. Moreover, the serum napsin A levels were not elevated in patients with pulmonary adenocarcinoma or renal dysfunction. The distinguishing point between IPF and the controls was that the area under the receiver operating characteristic curve (ROC) of napsin A was larger than that of KL-6, SP-A, or SP-D. CONCLUSION: These findings suggest that serum napsin A may be a candidate biomarker for IPF. BioMed Central 2012-09-11 /pmc/articles/PMC3515468/ /pubmed/22963039 http://dx.doi.org/10.1186/1471-2466-12-55 Text en Copyright ©2012 Samukawa et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Samukawa, Takuya
Hamada, Tsutomu
Uto, Hirofumi
Yanagi, Masakazu
Tsukuya, Go
Nosaki, Tsuyoshi
Maeda, Masahiro
Hirano, Takashi
Tsubouchi, Hirohito
Inoue, Hiromasa
The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
title The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
title_full The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
title_fullStr The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
title_full_unstemmed The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
title_short The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
title_sort elevation of serum napsin a in idiopathic pulmonary fibrosis, compared with kl-6, surfactant protein-a and surfactant protein-d
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515468/
https://www.ncbi.nlm.nih.gov/pubmed/22963039
http://dx.doi.org/10.1186/1471-2466-12-55
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