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Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease

BACKGROUND: Visual dysfunction is common in Parkinson’s disease (PD). It remains, however, unknown whether it is related to structural alterations of the retina. The aim of this study is to compare visual field (VF) findings and circumpapillary retinal nerve fiber layer (RNFL) thickness in a series...

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Autores principales: Tsironi, Evangelia E, Dastiridou, Anna, Katsanos, Andreas, Dardiotis, Efthymios, Veliki, Stella, Patramani, Gianna, Zacharaki, Fani, Ralli, Stella, Hadjigeorgiou, Georgios M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515471/
https://www.ncbi.nlm.nih.gov/pubmed/23031247
http://dx.doi.org/10.1186/1471-2415-12-54
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author Tsironi, Evangelia E
Dastiridou, Anna
Katsanos, Andreas
Dardiotis, Efthymios
Veliki, Stella
Patramani, Gianna
Zacharaki, Fani
Ralli, Stella
Hadjigeorgiou, Georgios M
author_facet Tsironi, Evangelia E
Dastiridou, Anna
Katsanos, Andreas
Dardiotis, Efthymios
Veliki, Stella
Patramani, Gianna
Zacharaki, Fani
Ralli, Stella
Hadjigeorgiou, Georgios M
author_sort Tsironi, Evangelia E
collection PubMed
description BACKGROUND: Visual dysfunction is common in Parkinson’s disease (PD). It remains, however, unknown whether it is related to structural alterations of the retina. The aim of this study is to compare visual field (VF) findings and circumpapillary retinal nerve fiber layer (RNFL) thickness in a series of PD patients and normal controls, in order to assess possible retinal anatomical changes and/or functional damage associated with PD. METHODS: PD patients and controls were recruited and underwent VF testing with static automated perimetry and RNFL examination with optical coherence tomography (OCT). Cognitive performance using Mini Mental State Examination (MMSE), PD staging using modified Hoehn and Yahr (H-Y) scale and duration of the disease was recorded in PD patients. RESULTS: One randomly selected eye from each of 24 patients and 24 age-matched controls was included. OCT RNFL thickness analysis revealed no difference in the inferior, superior, nasal or temporal sectors between the groups. The average peripapillary RNFL was also similar in the two groups. However, perimetric indices of generalized sensitivity loss (mean deviation) and localized scotomas (pattern standard deviation) were worse in patients with PD compared to controls (p < 0.01). 73% of eyes of PD patients had glaucomatous-like asymmetrical hemifield defects with abnormal Glaucoma Hemifield Test and various combinations of arcuate defects (n = 12), nasal steps (n = 11) and paracentral scotomas (n = 16). Bilateral defects were found in 14 patients (58%). No correlation was found between VF indices and MMSE or H-Y scores. CONCLUSION: PD patients may demonstrate glaucomatous-like perimetric defects even in the absence of decreased RNFL thickness.
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spelling pubmed-35154712012-12-06 Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease Tsironi, Evangelia E Dastiridou, Anna Katsanos, Andreas Dardiotis, Efthymios Veliki, Stella Patramani, Gianna Zacharaki, Fani Ralli, Stella Hadjigeorgiou, Georgios M BMC Ophthalmol Research Article BACKGROUND: Visual dysfunction is common in Parkinson’s disease (PD). It remains, however, unknown whether it is related to structural alterations of the retina. The aim of this study is to compare visual field (VF) findings and circumpapillary retinal nerve fiber layer (RNFL) thickness in a series of PD patients and normal controls, in order to assess possible retinal anatomical changes and/or functional damage associated with PD. METHODS: PD patients and controls were recruited and underwent VF testing with static automated perimetry and RNFL examination with optical coherence tomography (OCT). Cognitive performance using Mini Mental State Examination (MMSE), PD staging using modified Hoehn and Yahr (H-Y) scale and duration of the disease was recorded in PD patients. RESULTS: One randomly selected eye from each of 24 patients and 24 age-matched controls was included. OCT RNFL thickness analysis revealed no difference in the inferior, superior, nasal or temporal sectors between the groups. The average peripapillary RNFL was also similar in the two groups. However, perimetric indices of generalized sensitivity loss (mean deviation) and localized scotomas (pattern standard deviation) were worse in patients with PD compared to controls (p < 0.01). 73% of eyes of PD patients had glaucomatous-like asymmetrical hemifield defects with abnormal Glaucoma Hemifield Test and various combinations of arcuate defects (n = 12), nasal steps (n = 11) and paracentral scotomas (n = 16). Bilateral defects were found in 14 patients (58%). No correlation was found between VF indices and MMSE or H-Y scores. CONCLUSION: PD patients may demonstrate glaucomatous-like perimetric defects even in the absence of decreased RNFL thickness. BioMed Central 2012-10-02 /pmc/articles/PMC3515471/ /pubmed/23031247 http://dx.doi.org/10.1186/1471-2415-12-54 Text en Copyright ©2012 Tsironi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tsironi, Evangelia E
Dastiridou, Anna
Katsanos, Andreas
Dardiotis, Efthymios
Veliki, Stella
Patramani, Gianna
Zacharaki, Fani
Ralli, Stella
Hadjigeorgiou, Georgios M
Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease
title Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease
title_full Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease
title_fullStr Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease
title_full_unstemmed Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease
title_short Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease
title_sort perimetric and retinal nerve fiber layer findings in patients with parkinson’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515471/
https://www.ncbi.nlm.nih.gov/pubmed/23031247
http://dx.doi.org/10.1186/1471-2415-12-54
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