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Developmental control of replication timing defines a new breed of chromosomal domains with a novel mechanism of chromatin unfolding
We recently identified a set of chromosome domains that are early replicating uniquely in pluripotent cells. Their switch from early to late replication occurs just prior to germ layer commitment, associated with a stable form of gene silencing that is difficult to reverse. Here, we discuss results...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515532/ https://www.ncbi.nlm.nih.gov/pubmed/23023599 http://dx.doi.org/10.4161/nucl.22318 |