Cargando…

Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial

OBJECTIVE: Both aerobic (AER) and resistance (RES) training, if maintained over a period of several months, reduce HbA1c levels in type 2 diabetes subjects. However, it is still unknown whether the short-term effects of these types of exercise on blood glucose are similar. Our objective was to asses...

Descripción completa

Detalles Bibliográficos
Autores principales: Bacchi, Elisabetta, Negri, Carlo, Trombetta, Maddalena, Zanolin, Maria Elisabetta, Lanza, Massimo, Bonora, Enzo, Moghetti, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515569/
https://www.ncbi.nlm.nih.gov/pubmed/23227155
http://dx.doi.org/10.1371/journal.pone.0049937
_version_ 1782252210574327808
author Bacchi, Elisabetta
Negri, Carlo
Trombetta, Maddalena
Zanolin, Maria Elisabetta
Lanza, Massimo
Bonora, Enzo
Moghetti, Paolo
author_facet Bacchi, Elisabetta
Negri, Carlo
Trombetta, Maddalena
Zanolin, Maria Elisabetta
Lanza, Massimo
Bonora, Enzo
Moghetti, Paolo
author_sort Bacchi, Elisabetta
collection PubMed
description OBJECTIVE: Both aerobic (AER) and resistance (RES) training, if maintained over a period of several months, reduce HbA1c levels in type 2 diabetes subjects. However, it is still unknown whether the short-term effects of these types of exercise on blood glucose are similar. Our objective was to assess whether there may be a difference in acute blood glucose changes after a single bout of AER or RES exercise. STUDY DESIGN: Twenty-five patients participating in the RAED2 Study, a RCT comparing AER and RES training in diabetic subjects, were submitted to continuous glucose monitoring during a 60-min exercise session and over the following 47 h. These measurements were performed after 10.9+0.4 weeks of training. Glucose concentration areas under the curve (AUC) during exercise, the subsequent night, and the 24-h period following exercise, as well as the corresponding periods of the non-exercise day, were assessed. Moreover, the low (LBGI) and high (HBGI) blood glucose indices, which summarize the duration and extent of hypoglycaemia or hyperglycaemia, respectively, were measured. RESULTS: AER and RES training similarly reduced HbA1c. Forty-eight hour glucose AUC was similar in both groups. However, a comparison of glucose AUC during the 60-min exercise period and the corresponding period of the non-exercise day showed that glucose levels were lower during exercise in the AER but not in the RES group (time-by-group interaction p = 0.04). Similar differences were observed in the nocturnal periods (time-by-group interaction p = 0.02). Accordingly, nocturnal LBGI was higher in the exercise day than in the non-exercise day in the AER (p = 0.012) but not in the RES group (p = 0.62). CONCLUSIONS: Although AER and RES training have similar long-term metabolic effects in diabetic subjects, the acute effects of single bouts of these exercise types differ, with a potential increase in late-onset hypoglycaemia risk after AER exercise. TRIAL REGISTRATION: ClinicalTrials.gov NCT01182948
format Online
Article
Text
id pubmed-3515569
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-35155692012-12-07 Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial Bacchi, Elisabetta Negri, Carlo Trombetta, Maddalena Zanolin, Maria Elisabetta Lanza, Massimo Bonora, Enzo Moghetti, Paolo PLoS One Research Article OBJECTIVE: Both aerobic (AER) and resistance (RES) training, if maintained over a period of several months, reduce HbA1c levels in type 2 diabetes subjects. However, it is still unknown whether the short-term effects of these types of exercise on blood glucose are similar. Our objective was to assess whether there may be a difference in acute blood glucose changes after a single bout of AER or RES exercise. STUDY DESIGN: Twenty-five patients participating in the RAED2 Study, a RCT comparing AER and RES training in diabetic subjects, were submitted to continuous glucose monitoring during a 60-min exercise session and over the following 47 h. These measurements were performed after 10.9+0.4 weeks of training. Glucose concentration areas under the curve (AUC) during exercise, the subsequent night, and the 24-h period following exercise, as well as the corresponding periods of the non-exercise day, were assessed. Moreover, the low (LBGI) and high (HBGI) blood glucose indices, which summarize the duration and extent of hypoglycaemia or hyperglycaemia, respectively, were measured. RESULTS: AER and RES training similarly reduced HbA1c. Forty-eight hour glucose AUC was similar in both groups. However, a comparison of glucose AUC during the 60-min exercise period and the corresponding period of the non-exercise day showed that glucose levels were lower during exercise in the AER but not in the RES group (time-by-group interaction p = 0.04). Similar differences were observed in the nocturnal periods (time-by-group interaction p = 0.02). Accordingly, nocturnal LBGI was higher in the exercise day than in the non-exercise day in the AER (p = 0.012) but not in the RES group (p = 0.62). CONCLUSIONS: Although AER and RES training have similar long-term metabolic effects in diabetic subjects, the acute effects of single bouts of these exercise types differ, with a potential increase in late-onset hypoglycaemia risk after AER exercise. TRIAL REGISTRATION: ClinicalTrials.gov NCT01182948 Public Library of Science 2012-12-05 /pmc/articles/PMC3515569/ /pubmed/23227155 http://dx.doi.org/10.1371/journal.pone.0049937 Text en © 2012 Bacchi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bacchi, Elisabetta
Negri, Carlo
Trombetta, Maddalena
Zanolin, Maria Elisabetta
Lanza, Massimo
Bonora, Enzo
Moghetti, Paolo
Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial
title Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial
title_full Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial
title_fullStr Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial
title_full_unstemmed Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial
title_short Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial
title_sort differences in the acute effects of aerobic and resistance exercise in subjects with type 2 diabetes: results from the raed2 randomized trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515569/
https://www.ncbi.nlm.nih.gov/pubmed/23227155
http://dx.doi.org/10.1371/journal.pone.0049937
work_keys_str_mv AT bacchielisabetta differencesintheacuteeffectsofaerobicandresistanceexerciseinsubjectswithtype2diabetesresultsfromtheraed2randomizedtrial
AT negricarlo differencesintheacuteeffectsofaerobicandresistanceexerciseinsubjectswithtype2diabetesresultsfromtheraed2randomizedtrial
AT trombettamaddalena differencesintheacuteeffectsofaerobicandresistanceexerciseinsubjectswithtype2diabetesresultsfromtheraed2randomizedtrial
AT zanolinmariaelisabetta differencesintheacuteeffectsofaerobicandresistanceexerciseinsubjectswithtype2diabetesresultsfromtheraed2randomizedtrial
AT lanzamassimo differencesintheacuteeffectsofaerobicandresistanceexerciseinsubjectswithtype2diabetesresultsfromtheraed2randomizedtrial
AT bonoraenzo differencesintheacuteeffectsofaerobicandresistanceexerciseinsubjectswithtype2diabetesresultsfromtheraed2randomizedtrial
AT moghettipaolo differencesintheacuteeffectsofaerobicandresistanceexerciseinsubjectswithtype2diabetesresultsfromtheraed2randomizedtrial