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Age-Related Differences in Test-Retest Reliability in Resting-State Brain Functional Connectivity

Resting-state functional MRI (rs-fMRI) has emerged as a powerful tool for investigating brain functional connectivity (FC). Research in recent years has focused on assessing the reliability of FC across younger subjects within and between scan-sessions. Test-retest reliability in resting-state funct...

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Autores principales: Song, Jie, Desphande, Alok S., Meier, Timothy B., Tudorascu, Dana L., Vergun, Svyatoslav, Nair, Veena A., Biswal, Bharat B., Meyerand, Mary E., Birn, Rasmus M., Bellec, Pierre, Prabhakaran, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515585/
https://www.ncbi.nlm.nih.gov/pubmed/23227153
http://dx.doi.org/10.1371/journal.pone.0049847
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author Song, Jie
Desphande, Alok S.
Meier, Timothy B.
Tudorascu, Dana L.
Vergun, Svyatoslav
Nair, Veena A.
Biswal, Bharat B.
Meyerand, Mary E.
Birn, Rasmus M.
Bellec, Pierre
Prabhakaran, Vivek
author_facet Song, Jie
Desphande, Alok S.
Meier, Timothy B.
Tudorascu, Dana L.
Vergun, Svyatoslav
Nair, Veena A.
Biswal, Bharat B.
Meyerand, Mary E.
Birn, Rasmus M.
Bellec, Pierre
Prabhakaran, Vivek
author_sort Song, Jie
collection PubMed
description Resting-state functional MRI (rs-fMRI) has emerged as a powerful tool for investigating brain functional connectivity (FC). Research in recent years has focused on assessing the reliability of FC across younger subjects within and between scan-sessions. Test-retest reliability in resting-state functional connectivity (RSFC) has not yet been examined in older adults. In this study, we investigated age-related differences in reliability and stability of RSFC across scans. In addition, we examined how global signal regression (GSR) affects RSFC reliability and stability. Three separate resting-state scans from 29 younger adults (18–35 yrs) and 26 older adults (55–85 yrs) were obtained from the International Consortium for Brain Mapping (ICBM) dataset made publically available as part of the 1000 Functional Connectomes project www.nitrc.org/projects/fcon_1000. 92 regions of interest (ROIs) with 5 cubic mm radius, derived from the default, cingulo-opercular, fronto-parietal and sensorimotor networks, were previously defined based on a recent study. Mean time series were extracted from each of the 92 ROIs from each scan and three matrices of z-transformed correlation coefficients were created for each subject, which were then used for evaluation of multi-scan reliability and stability. The young group showed higher reliability of RSFC than the old group with GSR (p-value = 0.028) and without GSR (p-value <0.001). Both groups showed a high degree of multi-scan stability of RSFC and no significant differences were found between groups. By comparing the test-retest reliability of RSFC with and without GSR across scans, we found significantly higher proportion of reliable connections in both groups without GSR, but decreased stability. Our results suggest that aging is associated with reduced reliability of RSFC which itself is highly stable within-subject across scans for both groups, and that GSR reduces the overall reliability but increases the stability in both age groups and could potentially alter group differences of RSFC.
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spelling pubmed-35155852012-12-07 Age-Related Differences in Test-Retest Reliability in Resting-State Brain Functional Connectivity Song, Jie Desphande, Alok S. Meier, Timothy B. Tudorascu, Dana L. Vergun, Svyatoslav Nair, Veena A. Biswal, Bharat B. Meyerand, Mary E. Birn, Rasmus M. Bellec, Pierre Prabhakaran, Vivek PLoS One Research Article Resting-state functional MRI (rs-fMRI) has emerged as a powerful tool for investigating brain functional connectivity (FC). Research in recent years has focused on assessing the reliability of FC across younger subjects within and between scan-sessions. Test-retest reliability in resting-state functional connectivity (RSFC) has not yet been examined in older adults. In this study, we investigated age-related differences in reliability and stability of RSFC across scans. In addition, we examined how global signal regression (GSR) affects RSFC reliability and stability. Three separate resting-state scans from 29 younger adults (18–35 yrs) and 26 older adults (55–85 yrs) were obtained from the International Consortium for Brain Mapping (ICBM) dataset made publically available as part of the 1000 Functional Connectomes project www.nitrc.org/projects/fcon_1000. 92 regions of interest (ROIs) with 5 cubic mm radius, derived from the default, cingulo-opercular, fronto-parietal and sensorimotor networks, were previously defined based on a recent study. Mean time series were extracted from each of the 92 ROIs from each scan and three matrices of z-transformed correlation coefficients were created for each subject, which were then used for evaluation of multi-scan reliability and stability. The young group showed higher reliability of RSFC than the old group with GSR (p-value = 0.028) and without GSR (p-value <0.001). Both groups showed a high degree of multi-scan stability of RSFC and no significant differences were found between groups. By comparing the test-retest reliability of RSFC with and without GSR across scans, we found significantly higher proportion of reliable connections in both groups without GSR, but decreased stability. Our results suggest that aging is associated with reduced reliability of RSFC which itself is highly stable within-subject across scans for both groups, and that GSR reduces the overall reliability but increases the stability in both age groups and could potentially alter group differences of RSFC. Public Library of Science 2012-12-05 /pmc/articles/PMC3515585/ /pubmed/23227153 http://dx.doi.org/10.1371/journal.pone.0049847 Text en © 2012 Song et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Song, Jie
Desphande, Alok S.
Meier, Timothy B.
Tudorascu, Dana L.
Vergun, Svyatoslav
Nair, Veena A.
Biswal, Bharat B.
Meyerand, Mary E.
Birn, Rasmus M.
Bellec, Pierre
Prabhakaran, Vivek
Age-Related Differences in Test-Retest Reliability in Resting-State Brain Functional Connectivity
title Age-Related Differences in Test-Retest Reliability in Resting-State Brain Functional Connectivity
title_full Age-Related Differences in Test-Retest Reliability in Resting-State Brain Functional Connectivity
title_fullStr Age-Related Differences in Test-Retest Reliability in Resting-State Brain Functional Connectivity
title_full_unstemmed Age-Related Differences in Test-Retest Reliability in Resting-State Brain Functional Connectivity
title_short Age-Related Differences in Test-Retest Reliability in Resting-State Brain Functional Connectivity
title_sort age-related differences in test-retest reliability in resting-state brain functional connectivity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515585/
https://www.ncbi.nlm.nih.gov/pubmed/23227153
http://dx.doi.org/10.1371/journal.pone.0049847
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