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WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling

The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin ta...

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Detalles Bibliográficos
Autores principales:	James, Richard G., Davidson, Kathryn C., Bosch, Katherine A., Biechele, Travis L., Robin, Nicholas C., Taylor, Russell J., Major, Michael B., Camp, Nathan D., Fowler, Kerry, Martins, Timothy J., Moon, Randall T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515623/ https://www.ncbi.nlm.nih.gov/pubmed/23227175 http://dx.doi.org/10.1371/journal.pone.0050457

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