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UV-Light Exposure of Insulin: Pharmaceutical Implications upon Covalent Insulin Dityrosine Dimerization and Disulphide Bond Photolysis

In this work we report the effects of continuous UV-light (276 nm, ∼2.20 W.m(−2)) excitation of human insulin on its absorption and fluorescence properties, structure and functionality. Continuous UV-excitation of the peptide hormone in solution leads to the progressive formation of tyrosine photo-p...

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Detalles Bibliográficos
Autores principales:	Correia, Manuel, Neves-Petersen, Maria Teresa, Jeppesen, Per Bendix, Gregersen, Søren, Petersen, Steffen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515625/ https://www.ncbi.nlm.nih.gov/pubmed/23227203 http://dx.doi.org/10.1371/journal.pone.0050733

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