Cargando…

UV-Light Exposure of Insulin: Pharmaceutical Implications upon Covalent Insulin Dityrosine Dimerization and Disulphide Bond Photolysis

In this work we report the effects of continuous UV-light (276 nm, ∼2.20 W.m(−2)) excitation of human insulin on its absorption and fluorescence properties, structure and functionality. Continuous UV-excitation of the peptide hormone in solution leads to the progressive formation of tyrosine photo-p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Correia, Manuel, Neves-Petersen, Maria Teresa, Jeppesen, Per Bendix, Gregersen, Søren, Petersen, Steffen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515625/ https://www.ncbi.nlm.nih.gov/pubmed/23227203 http://dx.doi.org/10.1371/journal.pone.0050733

Ejemplares similares

Novel Covalently Linked Insulin Dimer Engineered to Investigate the Function of Insulin Dimerization
por: Vinther, Tine N., et al.
Publicado: (2012)

The Dynamic Effects of Isosteviol on Insulin Secretion and Its Inability to Counteract the Impaired β-Cell Function during Gluco-, Lipo-, and Aminoacidotoxicity: Studies In Vitro
por: Gu, Wenqian, et al.
Publicado: (2018)

Pharmaceutical compounds photolysis: pH influence
por: Kounaris Fuziki, Maria Eduarda, et al.
Publicado: (2023)

Photolysis of sulfamethazine using UV irradiation in an aqueous medium
por: Yi, Zhigang, et al.
Publicado: (2018)

Steviol glucuronide, a metabolite of steviol glycosides, potently stimulates insulin secretion from isolated mouse islets: Studies in vitro
por: Gu, Wenqian, et al.
Publicado: (2019)

Effect of UV-A, UV-B and UV-C irradiation of glyphosate on photolysis and mitigation of aquatic toxicity
por: Papagiannaki, Dimitra, et al.
Publicado: (2020)

Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance
por: Rafiq, Shamaila, et al.
Publicado: (2021)

Spatio-temporal photolysis rate profiles of UV(254) irradiated toluene
por: El-Tawargy, Ahmed S.
Publicado: (2022)

Analysis of N-nitrosodiethylamine by ion chromatography coupled with UV photolysis pretreatment
por: Li, Xueli, et al.
Publicado: (2016)

Insulin Resistance Is Inversely Associated with the Status of Vitamin D in Both Diabetic and Non-Diabetic Populations
por: Rafiq, Shamaila, et al.
Publicado: (2021)

Statistical Analysis of Methotrexate Degradation by UV-C Photolysis and UV-C/TiO(2) Photocatalysis
por: González-Burciaga, Luis A., et al.
Publicado: (2023)

Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization
por: Sahin, Cagla, et al.
Publicado: (2022)

Ecotoxicity and genotoxicity assessment of losartan after UV/H(2)O(2) and UVC/photolysis treatments
por: Adams, Eliane, et al.
Publicado: (2020)

A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome
por: Shokouh, Pedram, et al.
Publicado: (2017)

Rapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation
por: Gast, Klaus, et al.
Publicado: (2017)

Chemically stable fluorescent anti-counterfeiting labels achieved by UV-induced photolysis of nanocellulose
por: Cheng, Hongrui, et al.
Publicado: (2021)

Disulphide Bridges of Phospholipase C of Chlamydomonas reinhardtii Modulates Lipid Interaction and Dimer Stability
por: Awasthi, Mayanka, et al.
Publicado: (2012)

Dityrosine cross-linking and its potential roles in Alzheimer’s disease
por: Maina, Mahmoud B., et al.
Publicado: (2023)

Thiol/Disulphide Homeostasis, Ischemia Modified Albumin, and Ferroxidase as Oxidative Stress Markers in Women with Obesity with Insulin Resistance
por: Ates, Elif, et al.
Publicado: (2019)

Estrogenic Effect Mechanism and Influencing Factors for Transformation Product Dimer Formed in Preservative Parabens Photolysis
por: Niu, Xiaolin, et al.
Publicado: (2023)

Enhanced UV Direct Photolysis and UV/H(2)O(2) for Oxidation of Triclosan and Ibuprofen in Synthetic Effluent: an Experimental Study
por: da Luz, Vilson Conrado, et al.
Publicado: (2022)

Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer
por: Gu, Miao, et al.
Publicado: (2018)

Tracking Fluorine during Aqueous Photolysis and Advanced UV Treatment of Fluorinated Phenols and Pharmaceuticals Using a Combined (19)F-NMR, Chromatography, and Mass Spectrometry Approach
por: Bhat, Akash P., et al.
Publicado: (2022)

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease
por: Al-Hilaly, Youssra K, et al.
Publicado: (2013)

Non-cytotoxic Dityrosine Photocrosslinked Polymeric Materials With Targeted Elastic Moduli
por: Camp, Christopher P., et al.
Publicado: (2020)

Changing mechanical properties of photopolymerized, dityrosine-crosslinked protein-based hydrogels
por: Haas, Sandra, et al.
Publicado: (2022)

Acute effects of the coffee diterpene cafestol on glucose metabolism in non-diabetic subjects with abdominal obesity
por: Mellbye, Fredrik Drews, et al.
Publicado: (2023)

The Chlamydia trachomatis PmpD adhesin forms higher order structures through disulphide-mediated covalent interactions
por: Paes, Wayne, et al.
Publicado: (2018)

Methylene blue degradation by the VUV/UV/persulfate process: Effect of pH on the roles of photolysis and oxidation
por: Wen, Dong, et al.
Publicado: (2020)

Modulating the Structure of EGFR with UV Light: New Possibilities in Cancer Therapy
por: Correia, Manuel, et al.
Publicado: (2014)

Inhibition of Insulin Degrading Enzyme and Insulin Degradation by UV-Killed Lactobacillus acidophilus
por: Neyazi, Nadia, et al.
Publicado: (2018)

Correction: Modulating the Structure of EGFR with UV Light: New Possibilities in Cancer Therapy
por: Correia, Manuel, et al.
Publicado: (2015)

Mechanistic Insight into the Degradation of Nitrosamines via Aqueous-Phase UV Photolysis or a UV-Based Advanced Oxidation Process: Quantum Mechanical Calculations
por: Minakata, Daisuke, et al.
Publicado: (2018)

The Acid Soluble Disulphide and Mixed Disulphide Levels of Some Normal Tissues and Transplanted Tumours
por: Calcutt, G., et al.
Publicado: (1970)

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth
por: Wördehoff, Michael M., et al.
Publicado: (2017)

Generation mechanism of hydroxyl radical species and its lifetime prediction during the plasma-initiated ultraviolet (UV) photolysis
por: Attri, Pankaj, et al.
Publicado: (2015)

UV(185+254 nm) photolysis of typical thiol collectors: decomposition efficiency, mineralization and formation of sulfur byproducts
por: Fu, Pingfeng, et al.
Publicado: (2019)

Characterization of a Sequential UV Photolysis-Biodegradation Process for Treatment of Decabrominated Diphenyl Ethers in Sorbent/Water Systems
por: Chang, Yi-Tang, et al.
Publicado: (2020)

A coupled UV photolysis-biodegradation process for the treatment of decabrominated diphenyl ethers in an aerobic novel bioslurry reactor
por: Chang, Yi-Tang, et al.
Publicado: (2020)

Impact of a Novel Insulin Management Service on Non-insulin Pharmaceutical Expenses
por: Schneider, John E., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p7j4q9ach5uluv65n1595kgs7b