Structural basis for recognition of 5′-phosphotyrosine adducts by TDP2

The DNA repair enzyme TDP2 resolves 5′-phosphotyrosyl-DNA adducts, and is responsible for resistance to anti-cancer drugs that target covalent topoisomerase-DNA complexes. TDP2 also participates in key signaling pathways during development and tumorigenesis, and cleaves a protein-RNA linkage during...

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Detalles Bibliográficos
Autores principales: Shi, Ke, Kurahashi, Kayo, Gao, Rui, Tsutakawa, Susan E, Tainer, John A, Pommier, Yves, Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515695/
https://www.ncbi.nlm.nih.gov/pubmed/23104058
http://dx.doi.org/10.1038/nsmb.2423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515695/
https://www.ncbi.nlm.nih.gov/pubmed/23104058
http://dx.doi.org/10.1038/nsmb.2423

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