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Structural basis for recognition of 5′-phosphotyrosine adducts by TDP2
The DNA repair enzyme TDP2 resolves 5′-phosphotyrosyl-DNA adducts, and is responsible for resistance to anti-cancer drugs that target covalent topoisomerase-DNA complexes. TDP2 also participates in key signaling pathways during development and tumorigenesis, and cleaves a protein-RNA linkage during...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515695/ https://www.ncbi.nlm.nih.gov/pubmed/23104058 http://dx.doi.org/10.1038/nsmb.2423 |