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Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis

BACKGROUND: The kidney is a major target organ for systemic amyloidosis that often affects the kidney including proteinura, and elevated serum creatinine (Cr). The correlation between amount of amyloid deposits and clinical parameters is not known. The aim of this study was to clarify correlation th...

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Autores principales: Kuroda, Takeshi, Tanabe, Naohito, Kobayashi, Daisuke, Wada, Yoko, Murakami, Shuichi, Nakano, Masaaki, Narita, Ichiei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515801/
https://www.ncbi.nlm.nih.gov/pubmed/23006903
http://dx.doi.org/10.1186/1471-2369-13-118
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author Kuroda, Takeshi
Tanabe, Naohito
Kobayashi, Daisuke
Wada, Yoko
Murakami, Shuichi
Nakano, Masaaki
Narita, Ichiei
author_facet Kuroda, Takeshi
Tanabe, Naohito
Kobayashi, Daisuke
Wada, Yoko
Murakami, Shuichi
Nakano, Masaaki
Narita, Ichiei
author_sort Kuroda, Takeshi
collection PubMed
description BACKGROUND: The kidney is a major target organ for systemic amyloidosis that often affects the kidney including proteinura, and elevated serum creatinine (Cr). The correlation between amount of amyloid deposits and clinical parameters is not known. The aim of this study was to clarify correlation the amyloid area in all renal biopsy specimen and clinical parameters. METHODS: Fifty-eight patients with an established diagnosis of AL amyloidosis participated in the study. All patients showed amyloid deposits in renal biopsies. We retrospectively investigated the correlation between clinical data and amyloid occupied area in whole renal biopsy specimens. RESULTS: The area occupied by amyloid was less than 10% in 57 of the 58 patients, and was under 2% in 40. For statistical analyses, %amyloid-positive areas were transformed to common logarithmic values (Log(10)%amyloid). Cr showed significant correlation with Log(10)%amyloid and estimated glomerular filtration rate (eGFR) showed the significant negative correlation. Patient age, cleatinine clearance (Ccr), blood urea nitorogen, and urinary protein was not significantly correlated with Log(10)%amyloid. The correlation with other clinical factors such as sex, and serum concentrations of total protein, albumin, immunoglobulins, compliments was evaluated. None of these factors significantly correlated with Log(10)%amyloid. According to sex- and age- adjusted multiple linear regression analysis, Log(10)%amyloid had significant positive association with Cr and significant negative association with eGFR. CONCLUSION: There is significant association between amyloid-positive area in renal tissue and renal function, especially Cr and eGFR. The level of Cr and eGFR may be a marker of amount of amyloid in renal tissue.
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spelling pubmed-35158012012-12-06 Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis Kuroda, Takeshi Tanabe, Naohito Kobayashi, Daisuke Wada, Yoko Murakami, Shuichi Nakano, Masaaki Narita, Ichiei BMC Nephrol Research Article BACKGROUND: The kidney is a major target organ for systemic amyloidosis that often affects the kidney including proteinura, and elevated serum creatinine (Cr). The correlation between amount of amyloid deposits and clinical parameters is not known. The aim of this study was to clarify correlation the amyloid area in all renal biopsy specimen and clinical parameters. METHODS: Fifty-eight patients with an established diagnosis of AL amyloidosis participated in the study. All patients showed amyloid deposits in renal biopsies. We retrospectively investigated the correlation between clinical data and amyloid occupied area in whole renal biopsy specimens. RESULTS: The area occupied by amyloid was less than 10% in 57 of the 58 patients, and was under 2% in 40. For statistical analyses, %amyloid-positive areas were transformed to common logarithmic values (Log(10)%amyloid). Cr showed significant correlation with Log(10)%amyloid and estimated glomerular filtration rate (eGFR) showed the significant negative correlation. Patient age, cleatinine clearance (Ccr), blood urea nitorogen, and urinary protein was not significantly correlated with Log(10)%amyloid. The correlation with other clinical factors such as sex, and serum concentrations of total protein, albumin, immunoglobulins, compliments was evaluated. None of these factors significantly correlated with Log(10)%amyloid. According to sex- and age- adjusted multiple linear regression analysis, Log(10)%amyloid had significant positive association with Cr and significant negative association with eGFR. CONCLUSION: There is significant association between amyloid-positive area in renal tissue and renal function, especially Cr and eGFR. The level of Cr and eGFR may be a marker of amount of amyloid in renal tissue. BioMed Central 2012-09-24 /pmc/articles/PMC3515801/ /pubmed/23006903 http://dx.doi.org/10.1186/1471-2369-13-118 Text en Copyright ©2012 Kuroda et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kuroda, Takeshi
Tanabe, Naohito
Kobayashi, Daisuke
Wada, Yoko
Murakami, Shuichi
Nakano, Masaaki
Narita, Ichiei
Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
title Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
title_full Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
title_fullStr Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
title_full_unstemmed Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
title_short Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
title_sort significant association between renal function and amyloid-positive area in renal biopsy specimens in al amyloidosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515801/
https://www.ncbi.nlm.nih.gov/pubmed/23006903
http://dx.doi.org/10.1186/1471-2369-13-118
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