Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo

N-(4-hydroxyphenyl) retinamide (4HPR, fenretinide) is a synthetic retinoid that has been tested in clinical trials as a cancer therapeutic and chemopreventive agent. Although 4HPR has been shown to be cytotoxic to many kinds of cancer cells, the underlying molecular mechanisms are only partially und...

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Detalles Bibliográficos
Autores principales: Xie, Hua, Zhu, Feng, Huang, Zunnan, Lee, Mee-Hyun, Kim, Dong Joon, Li, Xiang, Lim, Do Young, Jung, Sung Keun, Kang, Soouk, Li, Haitao, Reddy, Kanamata, Wang, Lei, Ma, Weiya, Lubet, Ronald A., Bode, Ann M, Dong, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Manuscript
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515856/
https://www.ncbi.nlm.nih.gov/pubmed/22798378
http://dx.doi.org/10.1093/carcin/bgs234

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