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Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction

INTRODUCTION: Cardiac function is influenced by bone marrow transplantation (BMT). Studies have shown the various cardiotoxic effects of high-dose chemotherapy. In this study, we aimed to determine the effects of BMT on cardiac systolic function using echocardiographic indices. MATERIALS AND METHODS...

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Autores principales: Piranfar, Mohammad A., Karvandi, Mersedeh, Yazdani, Shahrooz, Pishgahi, Mehdi, Mehdizadeh, Mahshid, Hajfathali, Abbas, Tabarraee, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516012/
https://www.ncbi.nlm.nih.gov/pubmed/23233776
http://dx.doi.org/10.4103/0975-3583.102713
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author Piranfar, Mohammad A.
Karvandi, Mersedeh
Yazdani, Shahrooz
Pishgahi, Mehdi
Mehdizadeh, Mahshid
Hajfathali, Abbas
Tabarraee, Mehdi
author_facet Piranfar, Mohammad A.
Karvandi, Mersedeh
Yazdani, Shahrooz
Pishgahi, Mehdi
Mehdizadeh, Mahshid
Hajfathali, Abbas
Tabarraee, Mehdi
author_sort Piranfar, Mohammad A.
collection PubMed
description INTRODUCTION: Cardiac function is influenced by bone marrow transplantation (BMT). Studies have shown the various cardiotoxic effects of high-dose chemotherapy. In this study, we aimed to determine the effects of BMT on cardiac systolic function using echocardiographic indices. MATERIALS AND METHODS: Patients with lymphoma (Hodgkin's and non-Hodgkin's), multiple myeloma, and solid tumors which were candidates for autologous BMT were selected. The tissue Doppler S wave velocity in left ventricular echocardiographic segments and the Swave velocity in right ventricle, the left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), and ejection fraction (EF) were measured before and after BMT. RESULTS: Nineteen patients studied. The mean systolic function variable measures were calculated before and after BMT. The tissue Doppler S mean decreased in the septal, lateral and anterior walls by 8%, 7.9%, and 4.9% (P = 0.017), respectively. The tissue Doppler S mean increased in the inferior, anteroseptal and posterior walls by 1%, 0.6%, and 6.1%, respectively (not significant). The right ventricle Doppler S mean decreased by 7.5% after BMT (P = 0.03). The LVEDD and LVESD decreased significantly by 4.8% (P = 0.003) and 3.3% (P = 0.015), respectively, following BMT. The ejection fraction increased by about 7% after BMT (P = 0.05). CONCLUSION: The tissue Doppler S increased in all LV walls in patients with an EF less than 47%; surprisingly, tissue Doppler S decreased in all patients with an EF greater than 47%; and the ejection fraction increased by 13.6% and 3.1% in patients with a pre-BMT EF less than 47% and above 47%, respectively.
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spelling pubmed-35160122012-12-11 Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction Piranfar, Mohammad A. Karvandi, Mersedeh Yazdani, Shahrooz Pishgahi, Mehdi Mehdizadeh, Mahshid Hajfathali, Abbas Tabarraee, Mehdi J Cardiovasc Dis Res Original Article INTRODUCTION: Cardiac function is influenced by bone marrow transplantation (BMT). Studies have shown the various cardiotoxic effects of high-dose chemotherapy. In this study, we aimed to determine the effects of BMT on cardiac systolic function using echocardiographic indices. MATERIALS AND METHODS: Patients with lymphoma (Hodgkin's and non-Hodgkin's), multiple myeloma, and solid tumors which were candidates for autologous BMT were selected. The tissue Doppler S wave velocity in left ventricular echocardiographic segments and the Swave velocity in right ventricle, the left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), and ejection fraction (EF) were measured before and after BMT. RESULTS: Nineteen patients studied. The mean systolic function variable measures were calculated before and after BMT. The tissue Doppler S mean decreased in the septal, lateral and anterior walls by 8%, 7.9%, and 4.9% (P = 0.017), respectively. The tissue Doppler S mean increased in the inferior, anteroseptal and posterior walls by 1%, 0.6%, and 6.1%, respectively (not significant). The right ventricle Doppler S mean decreased by 7.5% after BMT (P = 0.03). The LVEDD and LVESD decreased significantly by 4.8% (P = 0.003) and 3.3% (P = 0.015), respectively, following BMT. The ejection fraction increased by about 7% after BMT (P = 0.05). CONCLUSION: The tissue Doppler S increased in all LV walls in patients with an EF less than 47%; surprisingly, tissue Doppler S decreased in all patients with an EF greater than 47%; and the ejection fraction increased by 13.6% and 3.1% in patients with a pre-BMT EF less than 47% and above 47%, respectively. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3516012/ /pubmed/23233776 http://dx.doi.org/10.4103/0975-3583.102713 Text en Copyright: © Journal of Cardiovascular Disease Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Piranfar, Mohammad A.
Karvandi, Mersedeh
Yazdani, Shahrooz
Pishgahi, Mehdi
Mehdizadeh, Mahshid
Hajfathali, Abbas
Tabarraee, Mehdi
Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction
title Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction
title_full Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction
title_fullStr Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction
title_full_unstemmed Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction
title_short Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction
title_sort bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516012/
https://www.ncbi.nlm.nih.gov/pubmed/23233776
http://dx.doi.org/10.4103/0975-3583.102713
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