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Blood Pressure in Relation to Age and Frailty

BACKGROUND AND PURPOSE: On average, systolic blood pressure (SBP) rises with age, while diastolic blood pressure (DBP) increases to age 50 and then declines. As elevated blood pressure is associated with cardiovascular disease and mortality, it also might be linked to frailty. We assessed the associ...

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Autores principales: Rockwood, Michael R.H., Howlett, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Canadian Geriatrics Society 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516342/
https://www.ncbi.nlm.nih.gov/pubmed/23251303
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author Rockwood, Michael R.H.
Howlett, Susan E.
author_facet Rockwood, Michael R.H.
Howlett, Susan E.
author_sort Rockwood, Michael R.H.
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description BACKGROUND AND PURPOSE: On average, systolic blood pressure (SBP) rises with age, while diastolic blood pressure (DBP) increases to age 50 and then declines. As elevated blood pressure is associated with cardiovascular disease and mortality, it also might be linked to frailty. We assessed the association between blood pressure, age, and frailty in a representative population-based cohort. METHODS: Individuals from the second clinical examination of the Canadian Study of Health and Aging (n = 2305, all 70+ years) were separated into four groups: history of hypertension ± antihypertensive medication, and no history of hypertension ± antihypertensive medication. Frailty was quantified as deficits accumulated in a frailty index (FI). RESULTS: SBP and DBP changed little in relation to age, except in untreated hypertension, where SBP declined in individuals >85 years. In contrast, SBP declined in all groups up to an FI of 0.55, and then rose sharply. DBP changed little in relation to FI. The slope of the line relating FI and age was highest in untreated individuals without a history of hypertension, indicating the highest physiological reserve. CONCLUSIONS: SBP declined as frailty increased in older adults, except at the highest FI levels. SBP and age had little or no relationship.
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spelling pubmed-35163422012-12-18 Blood Pressure in Relation to Age and Frailty Rockwood, Michael R.H. Howlett, Susan E. Can Geriatr J Original Research BACKGROUND AND PURPOSE: On average, systolic blood pressure (SBP) rises with age, while diastolic blood pressure (DBP) increases to age 50 and then declines. As elevated blood pressure is associated with cardiovascular disease and mortality, it also might be linked to frailty. We assessed the association between blood pressure, age, and frailty in a representative population-based cohort. METHODS: Individuals from the second clinical examination of the Canadian Study of Health and Aging (n = 2305, all 70+ years) were separated into four groups: history of hypertension ± antihypertensive medication, and no history of hypertension ± antihypertensive medication. Frailty was quantified as deficits accumulated in a frailty index (FI). RESULTS: SBP and DBP changed little in relation to age, except in untreated hypertension, where SBP declined in individuals >85 years. In contrast, SBP declined in all groups up to an FI of 0.55, and then rose sharply. DBP changed little in relation to FI. The slope of the line relating FI and age was highest in untreated individuals without a history of hypertension, indicating the highest physiological reserve. CONCLUSIONS: SBP declined as frailty increased in older adults, except at the highest FI levels. SBP and age had little or no relationship. Canadian Geriatrics Society 2011-04-13 /pmc/articles/PMC3516342/ /pubmed/23251303 Text en © 2011 Author(s). Published by the Canadian Geriatrics Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No-Derivative license (http://creativecommons.org/licenses/by-nc-nd/2.5/ca/), which permits unrestricted non-commercial use and distribution, provided the original work is properly cited.
spellingShingle Original Research
Rockwood, Michael R.H.
Howlett, Susan E.
Blood Pressure in Relation to Age and Frailty
title Blood Pressure in Relation to Age and Frailty
title_full Blood Pressure in Relation to Age and Frailty
title_fullStr Blood Pressure in Relation to Age and Frailty
title_full_unstemmed Blood Pressure in Relation to Age and Frailty
title_short Blood Pressure in Relation to Age and Frailty
title_sort blood pressure in relation to age and frailty
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516342/
https://www.ncbi.nlm.nih.gov/pubmed/23251303
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