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Insomnia and Endothelial Function – The HUNT 3 Fitness Study

BACKGROUND: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to asse...

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Autores principales: Strand, Linn B., Laugsand, Lars E., Skaug, Eli-Anne, Ellingsen, Øyvind, Madssen, Erik, Wisløff, Ulrik, Vatten, Lars, Janszky, Imre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516514/
https://www.ncbi.nlm.nih.gov/pubmed/23236412
http://dx.doi.org/10.1371/journal.pone.0050933
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author Strand, Linn B.
Laugsand, Lars E.
Skaug, Eli-Anne
Ellingsen, Øyvind
Madssen, Erik
Wisløff, Ulrik
Vatten, Lars
Janszky, Imre
author_facet Strand, Linn B.
Laugsand, Lars E.
Skaug, Eli-Anne
Ellingsen, Øyvind
Madssen, Erik
Wisløff, Ulrik
Vatten, Lars
Janszky, Imre
author_sort Strand, Linn B.
collection PubMed
description BACKGROUND: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to assess the association of insomnia with endothelial function in a large population based study of healthy individuals. METHODS: A total of 4 739 participants free from known cardiovascular or pulmonary diseases, cancer, and sarcoidosis, and who were not using antihypertensive medication were included in the study. They reported how often they had experienced difficulties falling asleep at night, repeated awakenings during the night, early awakenings without being able to go back to sleep, and daytime sleepiness. Endothelial function was measured by flow mediated dilation (FMD) derived from the brachial artery. RESULTS: We found no consistent association between the insomnia symptoms and endothelial function in multiadjusted models, but individual insomnia symptoms may be related to endothelial function. Among women who reported early awakenings, endothelial function may be lower than in women without this symptom (p = 0.03). CONCLUSIONS: This study provided no evidence that endothelial function, an early indicator of atherosclerosis, is an important linking factor between insomnia and CHD. Further studies are needed to explore the complex interrelation between sleep and cardiovascular pathology.
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spelling pubmed-35165142012-12-12 Insomnia and Endothelial Function – The HUNT 3 Fitness Study Strand, Linn B. Laugsand, Lars E. Skaug, Eli-Anne Ellingsen, Øyvind Madssen, Erik Wisløff, Ulrik Vatten, Lars Janszky, Imre PLoS One Research Article BACKGROUND: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to assess the association of insomnia with endothelial function in a large population based study of healthy individuals. METHODS: A total of 4 739 participants free from known cardiovascular or pulmonary diseases, cancer, and sarcoidosis, and who were not using antihypertensive medication were included in the study. They reported how often they had experienced difficulties falling asleep at night, repeated awakenings during the night, early awakenings without being able to go back to sleep, and daytime sleepiness. Endothelial function was measured by flow mediated dilation (FMD) derived from the brachial artery. RESULTS: We found no consistent association between the insomnia symptoms and endothelial function in multiadjusted models, but individual insomnia symptoms may be related to endothelial function. Among women who reported early awakenings, endothelial function may be lower than in women without this symptom (p = 0.03). CONCLUSIONS: This study provided no evidence that endothelial function, an early indicator of atherosclerosis, is an important linking factor between insomnia and CHD. Further studies are needed to explore the complex interrelation between sleep and cardiovascular pathology. Public Library of Science 2012-12-06 /pmc/articles/PMC3516514/ /pubmed/23236412 http://dx.doi.org/10.1371/journal.pone.0050933 Text en © 2012 Strand et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Strand, Linn B.
Laugsand, Lars E.
Skaug, Eli-Anne
Ellingsen, Øyvind
Madssen, Erik
Wisløff, Ulrik
Vatten, Lars
Janszky, Imre
Insomnia and Endothelial Function – The HUNT 3 Fitness Study
title Insomnia and Endothelial Function – The HUNT 3 Fitness Study
title_full Insomnia and Endothelial Function – The HUNT 3 Fitness Study
title_fullStr Insomnia and Endothelial Function – The HUNT 3 Fitness Study
title_full_unstemmed Insomnia and Endothelial Function – The HUNT 3 Fitness Study
title_short Insomnia and Endothelial Function – The HUNT 3 Fitness Study
title_sort insomnia and endothelial function – the hunt 3 fitness study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516514/
https://www.ncbi.nlm.nih.gov/pubmed/23236412
http://dx.doi.org/10.1371/journal.pone.0050933
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