Potential Role of Sodium-Proton Exchangers in the Low Concentration Arsenic Trioxide-Increased Intracellular pH and Cell Proliferation

Arsenic main inorganic compound is arsenic trioxide (ATO) presented in solution mainly as arsenite. ATO increases intracellular pH (pHi), cell proliferation and tumor growth. Sodium-proton exchangers (NHEs) modulate the pHi, with NHE1 playing significant roles. Whether ATO-increased cell proliferati...

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Detalles Bibliográficos
Autores principales: Aravena, Carmen, Beltrán, Ana R., Cornejo, Marcelo, Torres, Viviana, Díaz, Emilce S., Guzmán-Gutiérrez, Enrique, Pardo, Fabián, Leiva, Andrea, Sobrevia, Luis, Ramírez, Marco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516555/
https://www.ncbi.nlm.nih.gov/pubmed/23236503
http://dx.doi.org/10.1371/journal.pone.0051451

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