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Attenuated Salmonella Typhimurium Lacking the Pathogenicity Island-2 Type 3 Secretion System Grow to High Bacterial Numbers inside Phagocytes in Mice
Intracellular replication within specialized vacuoles and cell-to-cell spread in the tissue are essential for the virulence of Salmonella enterica. By observing infection dynamics at the single-cell level in vivo, we have discovered that the Salmonella pathogenicity island 2 (SPI-2) type 3 secretory...
Autores principales: | Grant, Andrew J., Morgan, Fiona J. E., McKinley, Trevelyan J., Foster, Gemma L., Maskell, Duncan J., Mastroeni, Pietro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516571/ https://www.ncbi.nlm.nih.gov/pubmed/23236281 http://dx.doi.org/10.1371/journal.ppat.1003070 |
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