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Reengineering the Collision Coupling and Diffusion Mode of the A(2A)-adenosine Receptor: PALMITOYLATION IN HELIX 8 RELIEVES CONFINEMENT

The A(2A)-adenosine receptor undergoes restricted collision coupling with its cognate G protein G(s) and lacks a palmitoylation site at the end of helix 8 in its intracellular C terminus. We explored the hypothesis that there was a causal link between the absence of a palmitoyl moiety and restricted...

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Detalles Bibliográficos
Autores principales:	Keuerleber, Simon, Thurner, Patrick, Gruber, Christian W., Zezula, Jürgen, Freissmuth, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516756/ https://www.ncbi.nlm.nih.gov/pubmed/23071116 http://dx.doi.org/10.1074/jbc.M112.393579

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