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Raltegravir use in special populations
Raltegravir, the first approved integrase inhibitor, has been shown to be virologically effective in Phase II and Phase III clinical trials in both treatment naïve and triple class resistant patients. It also has an excellent tolerability profile and lacks significant drug-drug interactions making i...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516827/ https://www.ncbi.nlm.nih.gov/pubmed/19959416 http://dx.doi.org/10.1186/2047-783X-14-S3-43 |
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author | Johnson, Margaret |
author_facet | Johnson, Margaret |
author_sort | Johnson, Margaret |
collection | PubMed |
description | Raltegravir, the first approved integrase inhibitor, has been shown to be virologically effective in Phase II and Phase III clinical trials in both treatment naïve and triple class resistant patients. It also has an excellent tolerability profile and lacks significant drug-drug interactions making it an important drug in the treatment of a number of special patient populations. In this review its use in patients undergoing solid organ and bone marrow transplantation and patients receiving cancer chemotherapy, will be discussed. In addition other indications including patients with metabolic complications of existing antiretroviral drugs as well as patients with side effects on current HAART regimens. Other groups of patients where raltegravir may play an important role are patients with renal disease and tuberculosis. Finally, although not licensed for use in pregnancy, raltegravir may need to be considered in some pregnant women with antiretroviral resistance or tolerability issues with current HAART regimens. |
format | Online Article Text |
id | pubmed-3516827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35168272012-12-11 Raltegravir use in special populations Johnson, Margaret Eur J Med Res Review Raltegravir, the first approved integrase inhibitor, has been shown to be virologically effective in Phase II and Phase III clinical trials in both treatment naïve and triple class resistant patients. It also has an excellent tolerability profile and lacks significant drug-drug interactions making it an important drug in the treatment of a number of special patient populations. In this review its use in patients undergoing solid organ and bone marrow transplantation and patients receiving cancer chemotherapy, will be discussed. In addition other indications including patients with metabolic complications of existing antiretroviral drugs as well as patients with side effects on current HAART regimens. Other groups of patients where raltegravir may play an important role are patients with renal disease and tuberculosis. Finally, although not licensed for use in pregnancy, raltegravir may need to be considered in some pregnant women with antiretroviral resistance or tolerability issues with current HAART regimens. BioMed Central 2009-11-24 /pmc/articles/PMC3516827/ /pubmed/19959416 http://dx.doi.org/10.1186/2047-783X-14-S3-43 Text en Copyright ©2009 I. Holzapfel Publishers |
spellingShingle | Review Johnson, Margaret Raltegravir use in special populations |
title | Raltegravir use in special populations |
title_full | Raltegravir use in special populations |
title_fullStr | Raltegravir use in special populations |
title_full_unstemmed | Raltegravir use in special populations |
title_short | Raltegravir use in special populations |
title_sort | raltegravir use in special populations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516827/ https://www.ncbi.nlm.nih.gov/pubmed/19959416 http://dx.doi.org/10.1186/2047-783X-14-S3-43 |
work_keys_str_mv | AT johnsonmargaret raltegraviruseinspecialpopulations |