More epigenetic hits than meets the eye: microRNAs and genes associated with the tumorigenesis of retinoblastoma

Retinoblastoma (RB), a childhood neoplasia of the retinoblasts, can occur unilaterally or bilaterally, with one or multiple foci per eye. RB is associated with somatic loss of function of both alleles of the tumor suppressor gene RB1. Hereditary forms emerge due to germline loss of function mutation...

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Detalles Bibliográficos
Autores principales: Reis, Adriana H. O., Vargas, Fernando R., Lemos, Bernardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516829/
https://www.ncbi.nlm.nih.gov/pubmed/23233862
http://dx.doi.org/10.3389/fgene.2012.00284

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