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Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers

Despite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load and massive CD4+ T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains an undetectable viral load. This infrequent...

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Detalles Bibliográficos
Autores principales: Herbeuval, Jean-Philippe, Smith, Nikaïa, Thèze, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517220/
https://www.ncbi.nlm.nih.gov/pubmed/23243424
http://dx.doi.org/10.1155/2012/869505
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author Herbeuval, Jean-Philippe
Smith, Nikaïa
Thèze, Jacques
author_facet Herbeuval, Jean-Philippe
Smith, Nikaïa
Thèze, Jacques
author_sort Herbeuval, Jean-Philippe
collection PubMed
description Despite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load and massive CD4+ T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains an undetectable viral load. This infrequent patient population is defined as HIV-1 controllers (HIV controllers), and represents less than 1% of HIV-1-infected patients. HIV-1-specific CD4+ T cells and the pool of central memory CD4+ T cells are also preserved despite immune activation due to HIV-1 infection. The majority of HIV controllers are also defined by the absence of massive CD4+ T-cell depletion, even after 10 years of infection. However, the mechanisms involved in protection against HIV-1 disease progression have not been elucidated yet. Controllers represent a heterogeneous population; we describe in this paper some common characteristics concerning innate immune response and CD4+ T cells of HIV controllers.
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spelling pubmed-35172202012-12-14 Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers Herbeuval, Jean-Philippe Smith, Nikaïa Thèze, Jacques Clin Dev Immunol Review Article Despite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load and massive CD4+ T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains an undetectable viral load. This infrequent patient population is defined as HIV-1 controllers (HIV controllers), and represents less than 1% of HIV-1-infected patients. HIV-1-specific CD4+ T cells and the pool of central memory CD4+ T cells are also preserved despite immune activation due to HIV-1 infection. The majority of HIV controllers are also defined by the absence of massive CD4+ T-cell depletion, even after 10 years of infection. However, the mechanisms involved in protection against HIV-1 disease progression have not been elucidated yet. Controllers represent a heterogeneous population; we describe in this paper some common characteristics concerning innate immune response and CD4+ T cells of HIV controllers. Hindawi Publishing Corporation 2012 2012-11-21 /pmc/articles/PMC3517220/ /pubmed/23243424 http://dx.doi.org/10.1155/2012/869505 Text en Copyright © 2012 Jean-Philippe Herbeuval et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Herbeuval, Jean-Philippe
Smith, Nikaïa
Thèze, Jacques
Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers
title Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers
title_full Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers
title_fullStr Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers
title_full_unstemmed Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers
title_short Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers
title_sort characteristics of plasmacytoid dendritic cell and cd4+ t cell in hiv elite controllers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517220/
https://www.ncbi.nlm.nih.gov/pubmed/23243424
http://dx.doi.org/10.1155/2012/869505
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