Cargando…

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck

BACKGROUND: Only a minority of cancer patients benefits from the combination of EGFR-inhibition and radiotherapy in head and neck squamous cell carcinoma (HNSCC). A potential resistance mechanism is activation of EGFR and/or downstream pathways by stimuli in the microenvironment. The aim of this stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stegeman, Hanneke, Kaanders, Johannes H, Wheeler, Deric L, van der Kogel, Albert J, Verheijen, Marieke M, Waaijer, Stijn J, Iida, Mari, Grénman, Reidar, Span, Paul N, Bussink, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517352/ https://www.ncbi.nlm.nih.gov/pubmed/23046567 http://dx.doi.org/10.1186/1471-2407-12-463

Ejemplares similares

Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines
por: Stegeman, Hanneke, et al.
Publicado: (2013)

Interaction between hypoxia, AKT and HIF-1 signaling in HNSCC and NSCLC: implications for future treatment strategies
por: Stegeman, Hanneke, et al.
Publicado: (2016)

Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma
por: van de Schootbrugge, Chantal, et al.
Publicado: (2014)

αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma
por: van de Schootbrugge, Chantal, et al.
Publicado: (2013)

Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4
por: Rademakers, Saskia E, et al.
Publicado: (2011)

Systematic analysis of (18)F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors
por: Hoeben, Bianca AW, et al.
Publicado: (2014)

Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell Lines
por: Göttgens, Eva-Leonne, et al.
Publicado: (2021)

Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas
por: Wijffels, K I E M, et al.
Publicado: (2000)

The Role of Hypoxia and the Immune System in Tumor Radioresistance
por: Span, Paul N., et al.
Publicado: (2019)

Letter to the editor: Hypoxia kinetics and histology in combined radiotherapy and oxidative phosphorylation inhibition effects on antitumor immunity
por: Boreel, Daan F, et al.
Publicado: (2021)

ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker
por: Göttgens, Eva-Leonne, et al.
Publicado: (2019)

Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells
por: Toulany, Mahmoud, et al.
Publicado: (2017)

Tumor Microenvironmental Changes Induced by the Sulfamate Carbonic Anhydrase IX Inhibitor S4 in a Laryngeal Tumor Model
por: Meijer, Tineke W. H., et al.
Publicado: (2014)

Prolyl Hydroxylase PHD3 Enhances the Hypoxic Survival and G1 to S Transition of Carcinoma Cells
por: Högel, Heidi, et al.
Publicado: (2011)

Multiparameter analysis of vasculature, perfusion and proliferation in human tumour xenografts.
por: Bussink, J., et al.
Publicado: (1998)

Uptake of [(18)F] EF5 as a Tracer for Hypoxic and Aggressive Phenotype in Experimental Head and Neck Squamous Cell Carcinoma()
por: Silén, Jonna, et al.
Publicado: (2014)

Quantitative Imaging of Hypoxic CAIX-Positive Tumor Areas with Low Immune Cell Infiltration in Syngeneic Mouse Tumor Models
por: Boreel, Daan F., et al.
Publicado: (2023)

Head and neck squamous cell carcinoma cell lines have an immunomodulatory effect on macrophages independent of hypoxia and toll-like receptor 9
por: Ishizu, Tamiko, et al.
Publicado: (2021)

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response
por: Nagelkerke, Anika, et al.
Publicado: (2013)

Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response
por: Wennemers, Marloes, et al.
Publicado: (2011)

Hypoxia, blood flow and metabolism in squamous-cell carcinoma of the head and neck: correlations between multiple immunohistochemical parameters and PET
por: Grönroos, Tove J, et al.
Publicado: (2014)

CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models
por: Huizing, Fokko J., et al.
Publicado: (2019)

Quantitative Imaging of the Hypoxia-Related Marker CAIX in Head and Neck Squamous Cell Carcinoma Xenograft Models
por: Huizing, Fokko J., et al.
Publicado: (2018)

Can FDG PET predict radiation treatment outcome in head and neck cancer? Results of a prospective study
por: Schinagl, Dominic A. X., et al.
Publicado: (2011)

Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes
por: Meijer, Tineke W.H., et al.
Publicado: (2019)

Epstein-Barr virus (EBV)-encoded small RNAs (EBERs) associated with poor prognosis of head and neck carcinomas
por: Aaro, Turunen, et al.
Publicado: (2017)

Polyomaviruses detectable in head and neck carcinomas
por: Poluschkin, Leonard, et al.
Publicado: (2018)

Imaging carbonic anhydrase IX as a method for monitoring hypoxia-related radioresistance in preclinical head and neck cancer models
por: Huizing, Fokko J., et al.
Publicado: (2021)

Yes and Lyn play a role in nuclear translocation of the Epidermal Growth Factor Receptor
por: Iida, Mari, et al.
Publicado: (2012)

Cancer cell line microarray as a novel screening method for identification of radioresistance biomarkers in head and neck squamous cell carcinoma
por: Routila, Johannes, et al.
Publicado: (2021)

AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer
por: Iida, Mari, et al.
Publicado: (2022)

Parametric mapping of immunohistochemically stained tissue sections; a method to quantify the colocalization of tumor markers
por: Rademakers, Saskia E., et al.
Publicado: (2011)

MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma
por: YATA, KAZUYA, et al.
Publicado: (2015)

(64)Cu-ATSM and (18)FDG PET uptake and (64)Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
por: Hansen, Anders E, et al.
Publicado: (2012)

Expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer
por: Span, P N, et al.
Publicado: (2009)

Endothelial microvesicles in hypoxic hypoxia diseases
por: Deng, Fan, et al.
Publicado: (2018)

Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription
por: Downes, Nicholas, et al.
Publicado: (2023)

Changes in DNA Damage Repair Gene Expression and Cell Cycle Gene Expression Do Not Explain Radioresistance in Tamoxifen-Resistant Breast Cancer
por: Post, Annemarie E. M., et al.
Publicado: (2020)

Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3
por: Brand, Toni M., et al.
Publicado: (2013)

Targeting CD44v6 for fluorescence-guided surgery in head and neck squamous cell carcinoma
por: Odenthal, Julia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jcosbgvig7086vbqpoah30u811