Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial

BACKGROUND: Severe TBI, defined as a Glasgow Coma Scale ≤ 8, increases intracranial pressure and activates the sympathetic nervous system. Sympathetic hyperactivity after TBI manifests as catecholamine excess, hypertension, abnormal heart rate variability, and agitation, and is associated with poor...

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Detalles Bibliográficos
Autores principales: Patel, Mayur B, McKenna, John W, Alvarez, JoAnn M, Sugiura, Ayaka, Jenkins, Judith M, Guillamondegui, Oscar D, Pandharipande, Pratik P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517360/
https://www.ncbi.nlm.nih.gov/pubmed/23013802
http://dx.doi.org/10.1186/1745-6215-13-177

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