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Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo

BACKGROUND: Many miR genes are located within or around CpG islands. It is unclear whether methylation of these CpG islands represses miR transcription regularly. The aims of this study are to characterize gastric carcinoma (GC)-related methylation of miR CpG islands and its relationship with miRNA...

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Detalles Bibliográficos
Autores principales: Du, Yantao, Liu, Zhaojun, Gu, Liankun, Zhou, Jing, Zhu, Bu-dong, Ji, Jiafu, Deng, Dajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517451/
https://www.ncbi.nlm.nih.gov/pubmed/22703336
http://dx.doi.org/10.1186/1471-2407-12-249