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Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature
BACKGROUND: Pulmonary carcinosarcoma is a biphasic tumour with an unfavourable prognosis. The differential diagnosis includes pulmonary blastoma and is often challenging. CASE PRESENTATION: We here describe a case of blastomatoid pulmonary carcinosarcoma in a 58-year-old patient, who underwent surgi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517474/ https://www.ncbi.nlm.nih.gov/pubmed/23006472 http://dx.doi.org/10.1186/1471-2407-12-424 |
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author | Schaefer, Inga-Marie Sahlmann, Carsten-Oliver Overbeck, Tobias Schweyer, Stefan Menke, Jan |
author_facet | Schaefer, Inga-Marie Sahlmann, Carsten-Oliver Overbeck, Tobias Schweyer, Stefan Menke, Jan |
author_sort | Schaefer, Inga-Marie |
collection | PubMed |
description | BACKGROUND: Pulmonary carcinosarcoma is a biphasic tumour with an unfavourable prognosis. The differential diagnosis includes pulmonary blastoma and is often challenging. CASE PRESENTATION: We here describe a case of blastomatoid pulmonary carcinosarcoma in a 58-year-old patient, who underwent surgical resection. Histopathological examination revealed immature glandular epithelium resembling high-grade fetal adenocarcinoma expressing epithelial markers and membranous beta-catenin, and blastomatoid spindle cells with partial rhabdomyosarcoma-like differentiation. Both elements expressed p53, MDM2, and cyclin-dependent kinase 4 (CDK4), but not thyroid-transcription factor 1 (TTF-1). Mutation analysis of KRAS, EGFR, and beta-catenin revealed no mutations. Comparative genomic hybridization detected +1q, +6p, +6q24qter, +8q, +11q12q14, +11q23qter, +12q12q21, +12q24qter, +17q, +20q, -5q14q23, -9p13pter, -13q21q21, and amplifications at 12q14q21, 15q24qter, 20q11q12. CONCLUSION: The observed molecular and cytogenetic findings may provide additional tools for the differential diagnosis of biphasic pulmonary neoplasms. Furthermore, TP53, MDM2, CDK4, and PTPN1 may be involved in tumourigenesis. |
format | Online Article Text |
id | pubmed-3517474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35174742012-12-08 Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature Schaefer, Inga-Marie Sahlmann, Carsten-Oliver Overbeck, Tobias Schweyer, Stefan Menke, Jan BMC Cancer Case Report BACKGROUND: Pulmonary carcinosarcoma is a biphasic tumour with an unfavourable prognosis. The differential diagnosis includes pulmonary blastoma and is often challenging. CASE PRESENTATION: We here describe a case of blastomatoid pulmonary carcinosarcoma in a 58-year-old patient, who underwent surgical resection. Histopathological examination revealed immature glandular epithelium resembling high-grade fetal adenocarcinoma expressing epithelial markers and membranous beta-catenin, and blastomatoid spindle cells with partial rhabdomyosarcoma-like differentiation. Both elements expressed p53, MDM2, and cyclin-dependent kinase 4 (CDK4), but not thyroid-transcription factor 1 (TTF-1). Mutation analysis of KRAS, EGFR, and beta-catenin revealed no mutations. Comparative genomic hybridization detected +1q, +6p, +6q24qter, +8q, +11q12q14, +11q23qter, +12q12q21, +12q24qter, +17q, +20q, -5q14q23, -9p13pter, -13q21q21, and amplifications at 12q14q21, 15q24qter, 20q11q12. CONCLUSION: The observed molecular and cytogenetic findings may provide additional tools for the differential diagnosis of biphasic pulmonary neoplasms. Furthermore, TP53, MDM2, CDK4, and PTPN1 may be involved in tumourigenesis. BioMed Central 2012-09-25 /pmc/articles/PMC3517474/ /pubmed/23006472 http://dx.doi.org/10.1186/1471-2407-12-424 Text en Copyright ©2012 Schaefer et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Schaefer, Inga-Marie Sahlmann, Carsten-Oliver Overbeck, Tobias Schweyer, Stefan Menke, Jan Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature |
title | Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature |
title_full | Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature |
title_fullStr | Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature |
title_full_unstemmed | Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature |
title_short | Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature |
title_sort | blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517474/ https://www.ncbi.nlm.nih.gov/pubmed/23006472 http://dx.doi.org/10.1186/1471-2407-12-424 |
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