Probable levetiracetam-related serum alkaline phosphatase elevation

BACKGROUND: Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function. CASE PRESENTATION: Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) du...

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Detalles Bibliográficos
Autores principales: Xiong, Nian, Hou, Lingling, Lu, Na, Mohamed, Asrah A, Wang, Tao, Huang, Yaling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517503/
https://www.ncbi.nlm.nih.gov/pubmed/22994584
http://dx.doi.org/10.1186/1471-2377-12-97
Descripción
Sumario:BACKGROUND: Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function. CASE PRESENTATION: Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) during LEV monotherapy. Moreover, the serum ALP level was surprisingly decreased to normal after LEV discontinuation. The Naranjo Adverse Drug Reaction Probability Scale score was 6, indicating firstly LEV was a probable cause for the increased serum ALP. CONCLUSIONS: Cautious usage and concerns of the LEV-associated potential ALP elevation should be considered when levetiracetam is prescribed to epilepsy patients, especially pediatric patients.

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