Probable levetiracetam-related serum alkaline phosphatase elevation

BACKGROUND: Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function. CASE PRESENTATION: Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) du...

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Autores principales: Xiong, Nian, Hou, Lingling, Lu, Na, Mohamed, Asrah A, Wang, Tao, Huang, Yaling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517503/
https://www.ncbi.nlm.nih.gov/pubmed/22994584
http://dx.doi.org/10.1186/1471-2377-12-97
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author Xiong, Nian
Hou, Lingling
Lu, Na
Mohamed, Asrah A
Wang, Tao
Huang, Yaling
author_facet Xiong, Nian
Hou, Lingling
Lu, Na
Mohamed, Asrah A
Wang, Tao
Huang, Yaling
author_sort Xiong, Nian
collection PubMed
description BACKGROUND: Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function. CASE PRESENTATION: Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) during LEV monotherapy. Moreover, the serum ALP level was surprisingly decreased to normal after LEV discontinuation. The Naranjo Adverse Drug Reaction Probability Scale score was 6, indicating firstly LEV was a probable cause for the increased serum ALP. CONCLUSIONS: Cautious usage and concerns of the LEV-associated potential ALP elevation should be considered when levetiracetam is prescribed to epilepsy patients, especially pediatric patients.
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spelling pubmed-35175032012-12-08 Probable levetiracetam-related serum alkaline phosphatase elevation Xiong, Nian Hou, Lingling Lu, Na Mohamed, Asrah A Wang, Tao Huang, Yaling BMC Neurol Case Report BACKGROUND: Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function. CASE PRESENTATION: Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) during LEV monotherapy. Moreover, the serum ALP level was surprisingly decreased to normal after LEV discontinuation. The Naranjo Adverse Drug Reaction Probability Scale score was 6, indicating firstly LEV was a probable cause for the increased serum ALP. CONCLUSIONS: Cautious usage and concerns of the LEV-associated potential ALP elevation should be considered when levetiracetam is prescribed to epilepsy patients, especially pediatric patients. BioMed Central 2012-09-20 /pmc/articles/PMC3517503/ /pubmed/22994584 http://dx.doi.org/10.1186/1471-2377-12-97 Text en Copyright ©2012 Xiong et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Xiong, Nian
Hou, Lingling
Lu, Na
Mohamed, Asrah A
Wang, Tao
Huang, Yaling
Probable levetiracetam-related serum alkaline phosphatase elevation
title Probable levetiracetam-related serum alkaline phosphatase elevation
title_full Probable levetiracetam-related serum alkaline phosphatase elevation
title_fullStr Probable levetiracetam-related serum alkaline phosphatase elevation
title_full_unstemmed Probable levetiracetam-related serum alkaline phosphatase elevation
title_short Probable levetiracetam-related serum alkaline phosphatase elevation
title_sort probable levetiracetam-related serum alkaline phosphatase elevation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517503/
https://www.ncbi.nlm.nih.gov/pubmed/22994584
http://dx.doi.org/10.1186/1471-2377-12-97
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