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The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis
BACKGROUND: The objective of this study was to conduct a systematic review with meta-analysis of studies assessing the association between living in an urban environment and the development of the Crohn’s disease (CD) or ulcerative colitis (UC). METHODS: A systematic literature search of MEDLINE (19...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517531/ https://www.ncbi.nlm.nih.gov/pubmed/22624994 http://dx.doi.org/10.1186/1471-230X-12-51 |
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author | Soon, Ing Shian Molodecky, Natalie A Rabi, Doreen M Ghali, William A Barkema, Herman W Kaplan, Gilaad G |
author_facet | Soon, Ing Shian Molodecky, Natalie A Rabi, Doreen M Ghali, William A Barkema, Herman W Kaplan, Gilaad G |
author_sort | Soon, Ing Shian |
collection | PubMed |
description | BACKGROUND: The objective of this study was to conduct a systematic review with meta-analysis of studies assessing the association between living in an urban environment and the development of the Crohn’s disease (CD) or ulcerative colitis (UC). METHODS: A systematic literature search of MEDLINE (1950-Oct. 2009) and EMBASE (1980-Oct. 2009) was conducted to identify studies investigating the relationship between urban environment and IBD. Cohort and case–control studies were analyzed using incidence rate ratio (IRR) or odds ratio (OR) with 95 % confidence intervals (CIs), respectively. Stratified and sensitivity analyses were performed to explore heterogeneity between studies and assess effects of study quality. RESULTS: The search strategy retrieved 6940 unique citations and 40 studies were selected for inclusion. Of these, 25 investigated the relationship between urban environment and UC and 30 investigated this relationship with CD. Included in our analysis were 7 case–control UC studies, 9 case–control CD studies, 18 cohort UC studies and 21 cohort CD studies. Based on a random effects model, the pooled IRRs for urban compared to rural environment for UC and CD studies were 1.17 (1.03, 1.32) and 1.42 (1.26, 1.60), respectively. These associations persisted across multiple stratified and sensitivity analyses exploring clinical and study quality factors. Heterogeneity was observed in the cohort studies for both UC and CD, whereas statistically significant heterogeneity was not observed for the case–control studies. CONCLUSIONS: A positive association between urban environment and both CD and UC was found. Heterogeneity may be explained by differences in study design and quality factors. |
format | Online Article Text |
id | pubmed-3517531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35175312012-12-08 The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis Soon, Ing Shian Molodecky, Natalie A Rabi, Doreen M Ghali, William A Barkema, Herman W Kaplan, Gilaad G BMC Gastroenterol Research Article BACKGROUND: The objective of this study was to conduct a systematic review with meta-analysis of studies assessing the association between living in an urban environment and the development of the Crohn’s disease (CD) or ulcerative colitis (UC). METHODS: A systematic literature search of MEDLINE (1950-Oct. 2009) and EMBASE (1980-Oct. 2009) was conducted to identify studies investigating the relationship between urban environment and IBD. Cohort and case–control studies were analyzed using incidence rate ratio (IRR) or odds ratio (OR) with 95 % confidence intervals (CIs), respectively. Stratified and sensitivity analyses were performed to explore heterogeneity between studies and assess effects of study quality. RESULTS: The search strategy retrieved 6940 unique citations and 40 studies were selected for inclusion. Of these, 25 investigated the relationship between urban environment and UC and 30 investigated this relationship with CD. Included in our analysis were 7 case–control UC studies, 9 case–control CD studies, 18 cohort UC studies and 21 cohort CD studies. Based on a random effects model, the pooled IRRs for urban compared to rural environment for UC and CD studies were 1.17 (1.03, 1.32) and 1.42 (1.26, 1.60), respectively. These associations persisted across multiple stratified and sensitivity analyses exploring clinical and study quality factors. Heterogeneity was observed in the cohort studies for both UC and CD, whereas statistically significant heterogeneity was not observed for the case–control studies. CONCLUSIONS: A positive association between urban environment and both CD and UC was found. Heterogeneity may be explained by differences in study design and quality factors. BioMed Central 2012-05-24 /pmc/articles/PMC3517531/ /pubmed/22624994 http://dx.doi.org/10.1186/1471-230X-12-51 Text en Copyright ©2012 Soon et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Soon, Ing Shian Molodecky, Natalie A Rabi, Doreen M Ghali, William A Barkema, Herman W Kaplan, Gilaad G The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis |
title | The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis |
title_full | The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis |
title_fullStr | The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis |
title_full_unstemmed | The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis |
title_short | The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis |
title_sort | relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517531/ https://www.ncbi.nlm.nih.gov/pubmed/22624994 http://dx.doi.org/10.1186/1471-230X-12-51 |
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