Cargando…
Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis
BACKGROUND: Takayasu arteritis (TA) is a rare form of chronic inflammatory granulomatous arteritis of the aorta and its major branches. Late gadolinium enhancement (LGE) with magnetic resonance imaging (MRI) has demonstrated its value for the detection of vessel wall alterations in TA. The aim of th...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517571/ https://www.ncbi.nlm.nih.gov/pubmed/23236382 http://dx.doi.org/10.1371/journal.pone.0050655 |
_version_ | 1782252444505341952 |
---|---|
author | Schneeweis, Christopher Schnackenburg, Bernhard Stuber, Matthias Berger, Alexander Schneider, Udo Yu, Jing Gebker, Rolf Weiss, Robert G. Fleck, Eckart Kelle, Sebastian |
author_facet | Schneeweis, Christopher Schnackenburg, Bernhard Stuber, Matthias Berger, Alexander Schneider, Udo Yu, Jing Gebker, Rolf Weiss, Robert G. Fleck, Eckart Kelle, Sebastian |
author_sort | Schneeweis, Christopher |
collection | PubMed |
description | BACKGROUND: Takayasu arteritis (TA) is a rare form of chronic inflammatory granulomatous arteritis of the aorta and its major branches. Late gadolinium enhancement (LGE) with magnetic resonance imaging (MRI) has demonstrated its value for the detection of vessel wall alterations in TA. The aim of this study was to assess LGE of the coronary artery wall in patients with TA compared to patients with stable CAD. METHODS: We enrolled 9 patients (8 female, average age 46±13 years) with proven TA. In the CAD group 9 patients participated (8 male, average age 65±10 years). Studies were performed on a commercial 3T whole-body MR imaging system (Achieva; Philips, Best, The Netherlands) using a 3D inversion prepared navigator gated spoiled gradient-echo sequence, which was repeated 34–45 minutes after low-dose gadolinium administration. RESULTS: No coronary vessel wall enhancement was observed prior to contrast in either group. Post contrast, coronary LGE on IR scans was detected in 28 of 50 segments (56%) seen on T2-Prep scans in TA and in 25 of 57 segments (44%) in CAD patients. LGE quantitative assessment of coronary artery vessel wall CNR post contrast revealed no significant differences between the two groups (CNR in TA: 6.0±2.4 and 7.3±2.5 in CAD; p = 0.474). CONCLUSION: Our findings suggest that LGE of the coronary artery wall seems to be common in patients with TA and similarly pronounced as in CAD patients. The observed coronary LGE seems to be rather unspecific, and differentiation between coronary vessel wall fibrosis and inflammation still remains unclear. |
format | Online Article Text |
id | pubmed-3517571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35175712012-12-12 Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis Schneeweis, Christopher Schnackenburg, Bernhard Stuber, Matthias Berger, Alexander Schneider, Udo Yu, Jing Gebker, Rolf Weiss, Robert G. Fleck, Eckart Kelle, Sebastian PLoS One Research Article BACKGROUND: Takayasu arteritis (TA) is a rare form of chronic inflammatory granulomatous arteritis of the aorta and its major branches. Late gadolinium enhancement (LGE) with magnetic resonance imaging (MRI) has demonstrated its value for the detection of vessel wall alterations in TA. The aim of this study was to assess LGE of the coronary artery wall in patients with TA compared to patients with stable CAD. METHODS: We enrolled 9 patients (8 female, average age 46±13 years) with proven TA. In the CAD group 9 patients participated (8 male, average age 65±10 years). Studies were performed on a commercial 3T whole-body MR imaging system (Achieva; Philips, Best, The Netherlands) using a 3D inversion prepared navigator gated spoiled gradient-echo sequence, which was repeated 34–45 minutes after low-dose gadolinium administration. RESULTS: No coronary vessel wall enhancement was observed prior to contrast in either group. Post contrast, coronary LGE on IR scans was detected in 28 of 50 segments (56%) seen on T2-Prep scans in TA and in 25 of 57 segments (44%) in CAD patients. LGE quantitative assessment of coronary artery vessel wall CNR post contrast revealed no significant differences between the two groups (CNR in TA: 6.0±2.4 and 7.3±2.5 in CAD; p = 0.474). CONCLUSION: Our findings suggest that LGE of the coronary artery wall seems to be common in patients with TA and similarly pronounced as in CAD patients. The observed coronary LGE seems to be rather unspecific, and differentiation between coronary vessel wall fibrosis and inflammation still remains unclear. Public Library of Science 2012-12-07 /pmc/articles/PMC3517571/ /pubmed/23236382 http://dx.doi.org/10.1371/journal.pone.0050655 Text en © 2012 Schneeweis et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Schneeweis, Christopher Schnackenburg, Bernhard Stuber, Matthias Berger, Alexander Schneider, Udo Yu, Jing Gebker, Rolf Weiss, Robert G. Fleck, Eckart Kelle, Sebastian Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis |
title | Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis |
title_full | Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis |
title_fullStr | Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis |
title_full_unstemmed | Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis |
title_short | Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis |
title_sort | delayed contrast-enhanced mri of the coronary artery wall in takayasu arteritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517571/ https://www.ncbi.nlm.nih.gov/pubmed/23236382 http://dx.doi.org/10.1371/journal.pone.0050655 |
work_keys_str_mv | AT schneeweischristopher delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT schnackenburgbernhard delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT stubermatthias delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT bergeralexander delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT schneiderudo delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT yujing delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT gebkerrolf delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT weissrobertg delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT fleckeckart delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis AT kellesebastian delayedcontrastenhancedmriofthecoronaryarterywallintakayasuarteritis |