Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-Terminal Fragments in an HEK293 Cell Model

BACKGROUND: N-terminal fragments of mutant huntingtin (htt) that terminate between residues 90–115, termed cleavage product A or 1 (cp-A/1), form intracellular and intranuclear inclusion bodies in the brains of patients with Huntington's disease (HD). These fragments appear to be proteolytic pr...

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Detalles Bibliográficos
Autores principales: Tebbenkamp, Andrew T. N., Crosby, Keith W., Siemienski, Zoe B., Brown, Hilda H., Golde, Todd E., Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517621/
https://www.ncbi.nlm.nih.gov/pubmed/23236391
http://dx.doi.org/10.1371/journal.pone.0050750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517621/
https://www.ncbi.nlm.nih.gov/pubmed/23236391
http://dx.doi.org/10.1371/journal.pone.0050750

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